Reference - Detail
| RRC ID | 89740 |
|---|---|
| Author | Machida A, Banshoya K, Okada R, Kameda Y, Kawamoto Y, Shibata S, Kaneo Y, Tanaka T, Ohnishi M. |
| Title | Therapeutic Potential of Water-Soluble Resveratrol-Loaded Polyethylene Glycol Monostearate Micelles in a Mouse Model of Dry Eye Disease. |
| Journal | Pharmazie |
| Abstract |
BACKGROUND:Dry eye disease (DED) is a multifactorial ocular surface condition that causes damage and discomfort, significantly impairing the quality of life of patients. Recently, phytochemicals such as trans-resveratrol (Res) have attracted growing interest due to their potential therapeutic effects against the DED-related pathophysiology. To enable the therapeutic application of water-insoluble Res, this study aimed to evaluate the efficacy of a previously developed water-soluble micelle formulation (stPEG/Res) containing polyethylene glycol monostearate (stPEG) in treating DED. METHODS:The antioxidant activity of stPEG/Res was assessed using the 2,2-diphenyl-1-picrylhydrazyl radical-scavenging assay, and its cytotoxicity was evaluated in a human corneal epithelial cell line. Furthermore, an in vivo efficacy study was performed using a mouse model of DED induced by lacrimal gland excision. Tear volume, corneal histopathological changes, inflammatory responses, and apoptosis in the cornea were evaluated. RESULTS:The stPEG/Res formulation exhibited antioxidant activity and a cytotoxicity profile against corneal epithelial cells comparable to that of free Res. Furthermore, in the mouse model of DED, stPEG/Res alleviated dry eye symptoms not by restoring tear volume, but by suppressing inflammation and apoptosis in the cornea. CONCLUSIONS:These findings indicate that stPEG/Res has potential as a novel therapeutic option for corneal disorders associated with DED. |
| Volume | 81(7) |
| Pages | 53494 |
| Published | 2026-7-21 |
| DOI | 10.31083/Pharmazie53494 |
| PII | S0031-7144(26)03301-0 |
| PMID | 42530079 |
| MeSH | Animals Antioxidants / administration & dosage Antioxidants / pharmacology Apoptosis / drug effects Cell Line Cornea / drug effects Cornea / pathology Disease Models, Animal Dry Eye Syndromes* / drug therapy Dry Eye Syndromes* / pathology Epithelial Cells / drug effects Epithelium, Corneal / drug effects Humans Male Mice Micelles Polyethylene Glycols* / chemistry Resveratrol* / administration & dosage Resveratrol* / pharmacology Solubility Tears Water / chemistry |
| Resource | |
| Human and Animal Cells | HCE-T(RCB2280) |