Reference - Detail
| RRC ID | 89757 |
|---|---|
| Author | Li J, Liu MJ, Du WJ, Peng XL, Deng H, Zi HX, Shang HB, Du JL. |
| Title | Neural-activity-regulated and glia-mediated control of brain lymphatic development. |
| Journal | Cell |
| Abstract |
The nervous system regulates peripheral immune responses under physiological and pathological conditions, but the brain's impact on immune system development remains unknown. Meningeal mural lymphatic endothelial cells (muLECs), embedded in the leptomeninges, form an immune niche surrounding the brain that contributes to brain immunosurveillance. Here, we report that the brain controls the development of muLECs via a specialized glial subpopulation, slc6a11b+ radial astrocytes (RAs), a process modulated by neural activity in zebrafish. slc6a11b+ RAs, with processes extending to the meninges, govern muLEC formation by expressing vascular endothelial growth factor C (vegfc). Moreover, neural activity regulates muLEC development, and this regulation requires Vegfc in slc6a11b+ RAs. Intriguingly, slc6a11b+ RAs cooperate with calcium-binding EGF domain 1 (ccbe1)+ fibroblasts to restrict muLEC growth on the brain surface via controlling mature Vegfc distribution. Thus, our study uncovers a glia-mediated and neural-activity-regulated control of brain lymphatic development and highlights the importance of inter-tissue cellular cooperation in development. |
| Volume | 188(12) |
| Pages | 3274-3290.e16 |
| Published | 2025-6-12 |
| DOI | 10.1016/j.cell.2025.04.008 |
| PII | S0092-8674(25)00410-6 |
| PMID | 40311620 |
| MeSH | Animals Astrocytes / metabolism Brain* / cytology Brain* / embryology Brain* / metabolism Endothelial Cells / cytology Endothelial Cells / metabolism Lymphangiogenesis* Lymphatic Vessels Meninges / cytology Meninges / metabolism Neuroglia* / metabolism Neurons / metabolism Vascular Endothelial Growth Factor C / metabolism Zebrafish / metabolism Zebrafish Proteins / metabolism |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 35 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | UAS:GFP, UAS:GCaMP6s |