Reference - Detail
| RRC ID | 89777 |
|---|---|
| Author | Obana S, Minato J, Takahashi S, Itakura S, Nishikawa M, Kusamori K. |
| Title | Human iPSC-derived mesenchymal progenitor cell sheets promote tissue formation after xenotransplantation. |
| Journal | iScience |
| Abstract |
Mesenchymal stromal cell (MSC) sheets are a promising platform for regenerative therapy, but their in vivo survival and capacity to form tissue-like structures remain poorly understood. Here, we investigated whether sheets derived from human induced pluripotent stem cell (iPSC)-derived mesenchymal progenitor cells (hiPS-MPCs) can survive and form tissue-like structures after xenotransplantation. hiPS-MPCs were differentiated from human iPSCs, validated by surface marker expression and multilineage differentiation potential, and assembled into intact cell sheets. Mouse MSC, fibroblast, and hiPS-MPC sheets were transplanted subcutaneously into immunocompetent mice. By day 7, mouse MSC and hiPS-MPC sheets formed organized vascularized tissue-like structures, whereas fibroblast sheets frequently induced inflammatory responses and showed limited persistence. Notably, hiPS-MPC-derived tissues exhibited reduced immune cell infiltration and higher expression of anti-inflammatory cytokines than fibroblast tissues. These findings demonstrate that hiPS-MPC sheets generate vascularized tissues in vivo and support survival across species, highlighting their potential as a scalable regenerative therapy platform. |
| Volume | 29(8) |
| Pages | 117128 |
| Published | 2026-8-21 |
| DOI | 10.1016/j.isci.2026.117128 |
| PII | S2589-0042(26)02506-X |
| PMID | 42620823 |
| PMC | PMC13486853 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 1.2 |
| Resource | |
| Human and Animal Cells | NIH3T3-3-4(RCB1862) |