| RRC ID |
89817
|
| Author |
Honda D, Okumura M, Oi A, Sakuma C, Obata F, Ando T, Miura M, Chihara T.
|
| Title |
The Hippo tumor suppressor pathway triggers non-cell autonomous tumorigenesis in Drosophila.
|
| Journal |
EMBO Rep
|
| Abstract |
The Hippo pathway is a tumor suppressor pathway, and most related studies have indicated that its inhibition leads to tumorigenesis. However, recent studies have suggested that the activated Hippo pathway can promote tumorigenesis in certain contexts. Here, we demonstrate that the activated Hippo pathway induces non-cell-autonomous tumorigenesis, characterized by tumor markers in the Drosophila wing epithelium. This suggests that Hippo-activated cells behave similarly to "oncogenic niche cells." We find that Hippo-activated cells induce Dronc-Wingless/Spitz signaling in the hinge/ventral notum region, which causes tumorigenesis. Moreover, we identify the amino acid transporters Sat1/2, which are implicated in amino acid incorporation and function redundantly with the growth factors Wingless and Spitz to facilitate non-cell-autonomous tumorigenesis.
|
| Volume |
27(11)
|
| Pages |
2915-2946
|
| Published |
2026-6-1
|
| DOI |
10.1038/s44319-026-00778-5
|
| PII |
10.1038/s44319-026-00778-5
|
| PMID |
42067646
|
| PMC |
PMC13261145
|
| MeSH |
Animals
Carcinogenesis* / genetics
Carcinogenesis* / metabolism
Drosophila* / metabolism
Drosophila Proteins* / genetics
Drosophila Proteins* / metabolism
Drosophila melanogaster* / genetics
Drosophila melanogaster* / metabolism
Hippo Kinases
Intracellular Signaling Peptides and Proteins* / genetics
Intracellular Signaling Peptides and Proteins* / metabolism
Protein Serine-Threonine Kinases* / genetics
Protein Serine-Threonine Kinases* / metabolism
Signal Transduction*
Wings, Animal / metabolism
Wings, Animal / pathology
Wnt1 Protein / metabolism
|
| Resource |
| Drosophila |
CAS-0001 |
