| RRC ID |
89835
|
| Author |
Takano A, Ogawa R, Miyamoto J, Umegaki N, Ban S, Yaguchi T, Kamei K, Tanaka M, Harada T, Ishizaki S.
|
| Title |
A Case of Phaeohyphomycosis Caused by Phaeoacremonium alvesii on the Dorsum of the Right Hand in Japan.
|
| Journal |
Med Mycol J
|
| Abstract |
A man in his seventies without immunocompromised background presented with a slowly enlarging skin lesion on the dorsum of his right hand that had developed 6 months prior to his visit to our hospital. At the initial examination, a 3-cm brownish plaque associated with mild pain was observed on the dorsum of the right hand. Histopathological examination revealed a mass of hyphae in the subcutaneous tissue that was positive for periodic acid-Schiff and Grocott's stains. Fungal culture of the skin tissue yielded black-brown, downy colonies. Based on nucleotide sequencing of the internal transcribed spacer region and the β-tubulin gene, the organism was identified as Phaeoacremonium alvesii. After oral administration of terbinafine (TBF) at 125 mg/day was initiated, the lesions gradually improved. The strain exhibited slightly reduced sensitivity to TBF (minimum inhibitory concentration: 1 μg/mL). More than six months of oral therapy was required to achieve remission of the skin lesions. P. alvesii is a recently classified species, redefined in 2005 based on β-tubulin gene analysis, with only a few reported cases of human infection.
|
| Volume |
67(1)
|
| Pages |
27-31
|
| Published |
2026-1-1
|
| DOI |
10.3314/mmj.25-00025
|
| PMID |
41765497
|
| MeSH |
Administration, Oral
Antifungal Agents / administration & dosage
Antifungal Agents / therapeutic use
Ascomycota* / classification
Ascomycota* / drug effects
Ascomycota* / genetics
Ascomycota* / isolation & purification
DNA, Fungal / chemistry
DNA, Fungal / genetics
DNA, Ribosomal Spacer / chemistry
DNA, Ribosomal Spacer / genetics
Hand* / microbiology
Hand* / pathology
Humans
Japan
Male
Microbial Sensitivity Tests
Naphthalenes / administration & dosage
Naphthalenes / therapeutic use
Phaeohyphomycosis* / diagnosis
Phaeohyphomycosis* / drug therapy
Phaeohyphomycosis* / microbiology
Phaeohyphomycosis* / pathology
Sequence Analysis, DNA
Skin / microbiology
Skin / pathology
Terbinafine
Treatment Outcome
Tubulin / genetics
|
| Resource |
| Pathogenic eukaryotic microorganisms |
Phaeoacremonium alvesii IFM 69216 |
