| RRC ID |
90104
|
| Author |
Liu ZF, Wang Q, Xiao JH, Wang JH, Li J, Han CJ, Jafari SM, Lu ZY.
|
| Title |
Bioactive carbon dots from peony seed meal for nanomedicine via circular economy.
|
| Journal |
iScience
|
| Abstract |
The valorization of agricultural waste into high-value nanomaterials is key to a sustainable circular economy. Here, we transform underutilized peony seed meal into nitrogen/oxygen-doped carbon dots (PSM-CDs) via a simple hydrothermal process. These PSM-CDs exhibit potent superoxide dismutase-mimetic activity, governed by surface carbonyl groups. In a hemolytic anemia model, they act as a dual-pathway therapeutic by scavenging reactive oxygen species and suppressing the NF-κB/NLRP3 axis, while promoting erythropoiesis via ROS-HIF-1 signaling, with excellent biosafety. This work establishes a scalable "waste-to-therapeutics" paradigm, bridging sustainable agriculture and nanomedicine development.
|
| Volume |
29(7)
|
| Pages |
116432
|
| Published |
2026-7-17
|
| DOI |
10.1016/j.isci.2026.116432
|
| PII |
S2589-0042(26)01807-9
|
| PMID |
42383013
|
| PMC |
PMC13315766
|
| Resource |
| Human and Animal Cells |
HUDEP-2(RCB4557) |
