| RRC ID |
947
|
| 著者 |
Vilela MM, Kamei K, Sano A, Tanaka R, Uno J, Takahashi I, Ito J, Yarita K, Miyaji M.
|
| タイトル |
Pathogenicity and virulence of Candida dubliniensis: comparison with C. albicans.
|
| ジャーナル |
Med Mycol
|
| Abstract |
Candida dubliniensis is a newly described fungus that is frequently isolated from the oral cavities of HIV-positive patients. Although extensive studies have been performed on the phylogeny of C. dubliniensis, little is known about the pathogenic ecology of this yeast. Here we examined aspects related to C. dubliniensis in comparison with those of C. albicans. When injected intravenously into mice, C. dubliniensis had a higher survival rate than C. albicans. Histopathological analysis disclosed that C. dubliniensis remained mostly in the yeast form in the infected organs, whereas C. albicans changed into the mycelial form. The host inflammatory reaction was aggressive with C. dubliniensis infection and mild with C. albicans infection. Co-culture of the yeasts with human polymorphonuclear leukocytes disclosed that C. dubliniensis is more vulnerable to the fungicidal activity of leukocytes than C. albicans. C. dubliniensis was also more susceptible to the toxic effect of hydrogen peroxide. When cultured in vitro, C. dubliniensis grew more slowly than C. albicans, but the formation of germ tubes was faster. When the fungi were cultured in RPMI 1640, a fetal bovine serum supplement suppressed the growth of C. dubliniensis but enhanced that of C. albicans. These results clearly indicated that C. dubliniensis is less virulence than C. albicans.
|
| 巻・号 |
40(3)
|
| ページ |
249-57
|
| 公開日 |
2002-6-1
|
| DOI |
10.1080/mmy.40.3.249.257
|
| PMID |
12146754
|
| MeSH |
Animals
Anti-Infective Agents, Local / pharmacology
Candida / drug effects
Candida / pathogenicity*
Candida albicans / drug effects
Candida albicans / pathogenicity
Candidiasis / blood
Candidiasis / microbiology*
Candidiasis / pathology
Coculture Techniques
Culture Media
Disease Models, Animal
Humans
Hydrogen Peroxide / pharmacology
Leukocytes, Mononuclear / immunology
Male
Mice
Species Specificity
Time Factors
Virulence
|
| IF |
2.822
|
| 引用数 |
50
|
|
WOS 分野
|
VETERINARY SCIENCES
MYCOLOGY
INFECTIOUS DISEASES
|
| リソース情報 |
| 病原微生物 |
IFM 40009
IFM 40213
IFM 48313
IFM 48314 |
