RRC ID 956
著者 Oarada M, Nikawa T, Kurita N.
タイトル Effect of timing of food deprivation on host resistance to fungal infection in mice.
ジャーナル Br J Nutr
Abstract Mice were deprived of food for a period of 72 h at varying times relative to the time of infection with Paracoccidioides brasiliensis. Host resistance was diminished profoundly when the period of food deprivation was from 48 h before to 24 h after infection (group B). When food deprivation was initiated immediately after infection (group C), host resistance was reduced less profoundly. When food deprivation was initiated at 24 and 48 h post-infection, reductions in host resistance were only moderate or not observed respectively. These results suggest that the earlier in the course of infection starvation occurs, the more profoundly host resistance is impaired. When food deprivation was initiated 72 h before infection, finishing at the time of infection (group A), the reduction in host resistance was considerably less profound compared with group B mice, suggesting that refeeding initiated immediately after infection is responsible for rapid restoration of the antifungal resistance in starved mice. Infection-induced responses of corticosterone and interferon-gamma were changed according to the timing of food deprivation. Group A mice, similar to non-fasted controls, showed an infection-induced increase in serum corticosterone concentration, while groups B and C did not. Group C mice showed a substantially greater infection-induced increase in serum interferon-gamma compared with the other fasted and non-fasted control groups.
巻・号 88(2)
ページ 151-8
公開日 2002-8-1
DOI 10.1079/BJNBJN2002600
PII S0007114502001472
PMID 12144718
MeSH Acute Disease Adrenocorticotropic Hormone / blood Animals Corticosterone / blood Female Food Deprivation / physiology* Immunity, Innate Interferon-gamma / blood Mice Mice, Inbred BALB C Paracoccidioides* Paracoccidioidomycosis / immunology* Specific Pathogen-Free Organisms Time Factors
IF 3.334
引用数 4
WOS 分野 NUTRITION & DIETETICS
リソース情報
病原微生物 IFM 41621