論文 - 詳細
| RRC ID | 977 |
|---|---|
| 著者 | Yoshida S, Sasakawa C. |
| タイトル | Exploiting host microtubule dynamics: a new aspect of bacterial invasion. |
| ジャーナル | Trends Microbiol |
| Abstract |
During infection, many pathogenic bacteria modulate the actin cytoskeleton of eukaryotic host cells to facilitate various infectious processes such as the attachment to or invasion of epithelial cells. Additionally, some pathogenic bacteria are capable of modulating the dynamics of host microtubule (MTs). Although the molecular basis for this is still poorly understood, a recent study of the Shigella VirA effector protein, which is delivered via a type III secretion system, suggests that MT destabilization plays an important role in Shigella infection. |
| 巻・号 | 11(3) |
| ページ | 139-43 |
| 公開日 | 2003-3-1 |
| DOI | 10.1016/s0966-842x(03)00023-4 |
| PII | S0966842X03000234 |
| PMID | 12648946 |
| MeSH | Actins / metabolism Animals Bacteria / pathogenicity* Bacterial Infections / microbiology Bacterial Infections / physiopathology Bacterial Proteins / metabolism Cell Line Eukaryotic Cells / metabolism* Eukaryotic Cells / microbiology Humans Mice Microtubules / metabolism* Shigella / pathogenicity Virulence Factors* |
| IF | 13.546 |
| 引用数 | 52 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY MICROBIOLOGY |
| リソース情報 | |
| 病原微生物 | Review |