Reference - RRC(Research Resource Circulation)

リソース情報
RRC ID	991
著者	Sharmin S, Kishi F, Sano A, Kamei K, Nishimura K, Miyaji M.
タイトル	Direct invasion of bones by highly pathogenic fungi in an in vitro model and its ecological significance.
ジャーナル	Nihon Ishinkin Gakkai Zasshi
Abstract	Animal bones after being devitalized at death are strongly resistant to wear and tear and remain in the soil or environment much longer than other organic components from dead animals. Yet over the course of time they seem to disappear and thus our ecological surroundings are not cluttered with bone remnants. Mechanical factors creating compression or friction and chemical factors like pH of the soil and surroundings must together have provided concerted degrading effects. Microorganisms in the soil also help in this process by utilizing the organic components of devitalized bones. Certain highly pathogenic fungi that have been collected from soil from time to time and many other environmental fungi may take part in the degrading of the bone remnants. In this study, several strains from the highly pathogenic dimorphic fungi Coccidioides immitis, Blastomyces dermatitidis, Histoplasma spp., Paracoccidioides brasiliensis and also some strains of dematiaceous fungi (Exophiala spp. and Foncecaea pedrosoi) were inoculated to dissected and devitalized murine long bones that had been placed on solidified water agar plates to see if they would survive, grow and invade the bones. After being kept for 12 weeks at 25 degrees C all the parts of the histological sections of these bones showed invasion by most of the strains used in this study, although the cortical component of the bony architecture seemed to be comparatively resistant to invasion. Their ability to grow and sporulate in the aforementioned nutrient-limiting condition hinted at a possible role of these fungi in the degradation of devitalized bones.
巻・号	44(1)
ページ	17-23
公開日	2003-1-1
DOI	10.3314/jjmm.44.17
PMID	12590255
MeSH	Animals Biodegradation, Environmental Bone and Bones / anatomy & histology Bone and Bones / metabolism* Bone and Bones / microbiology* Culture Media Ecosystem Fungi / growth & development Fungi / physiology* In Vitro Techniques Male Mice Mice, Inbred Strains Models, Theoretical
病原微生物	IFM 4827 IFM 4935 IFM 4945 IFM 5396 IFM 5416 IFM 5417 IFM 5418 IFM 41314 IFM 41315 IFM 41316 IFM 41317 IFM 41318 IFM 41329 IFM 41332 IFM 41333 IFM 41334 IFM 41335 IFM 41505 IFM 41598 IFM 41620 IFM 41621 IFM 41624 IFM 41625 IFM 41626 IFM 41628 IFM 41630 IFM 41632 IFM 41633 IFM 45809 IFM 45810 IFM 45811 IFM 45812 IFM 45813 IFM 45815 IFM 45816 IFM 45817 IFM 45868 IFM 46215 IFM 46463 IFM 46927 IFM 47060 IFM 47068 IFM 47069 IFM 47183 IFM 47195 IFM 47207 IFM 47217 IFM 47750 IFM 49109 IFM 49627 IFM 49721 IFM 50225 IFM 50545 IFM 50954 IFM 50992 IFM 50993 IFM 50994 IFM 50995 IFM 41612?

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