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  • Search Condition : Filter (MeSH = Cell Cycle Proteins* / genetics)
Species Resource Title
Yeast Protection and deprotection of the Rec8 cohesin complex during meiosis.
Yeast FY13012 , FY9954 A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1-1 phosphorylation to activate the DNA replication checkpoint.
Human and Animal Cells CW-2(RCB0778) NDRG1 expression in cancers confers dependence on DNA damage repair and sensitivity to quinacrine.
C.elegans tm2543 A nuclear TRiC/CCT chaperonin assembles meiotic HORMAD proteins into chromosome axes competent for crossing over.
C.elegans tm925 C. elegans SAS-1 ensures centriole integrity and ciliary function, and operates with SSNA-1.
C.elegans tm1937 , tm1145 Separation-of-Function Alleles of smc-5 Reveal Domain-Specific Defects and a Conserved Residue Critical for Genome Maintenance.
Human and Animal Cells Kato III(RCB2088) , NUGC-4(RCB1939) , MKN7(RCB0999) , HGC-27(RCB0500) , MKN45(RCB1001) , MKN74(RCB1002) , WI-38(RCB0702) Overexpression of JMJD6 drives immune evasion via the BRD4-IRF1-PD-L1 axis and promotes malignancy in gastric cancer.
Yeast Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation.
Mice RBRC00661 Hybrid female sterility due to cohesin protection errors in mouse oocytes.
Yeast FY19706 Mutual, spatially limited control of meiotic DNA break formation by Mre11-Rad50-Nbs1 DNA repair complex and Tel1 (ATM) protein kinase.
Mice RBRC09508 BRD4 and MYB inhibition overcomes venetoclax resistance in EVI1-rearranged acute myeloid leukemia.
Human and Animal Cells BHK-21(RCB1423) Acute-onset axonal neuropathy following infection in children with biallelic RCC1 variants: a case series.
Yeast FY24592 , FY40844 , FY13814 , FY8770 , FY24011 Balance of polo-like kinase Plo1 and monopolar attachment protein 1 (Moa1) regulates fission yeast meiosis.
DNA material , Human and Animal Cells CSII-CMV-MCS-IRES2-Bsd (RDB04385) , pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394) , 201B7(HPS0063) Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells.
C.elegans tm2543 Overlapping and separable activities of BRA-2 and HIM-17 promote occurrence and regulation of pairing and synapsis during Caenorhabditis elegans meiosis.
Human and Animal Cells HeLa(RCB0007) Human RCC1L is involved in the maintenance of mitochondrial nucleoids and mtDNA.
DNA material CSII-CMV-AFF4T254S-IRES2-Bsd (RDB21100) , pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) , CSII-CMV-MCS-IRES2-Bsd (RDB04385) A common molecular mechanism underlying Cornelia de Lange and CHOPS syndromes.
Yeast The ortholog of human DNAJC9 promotes histone H3-H4 degradation and is counteracted by Asf1 in fission yeast.
DNA material , Human and Animal Cells pMRX-IPU-muGFP-OPTN delta UBAN (RDB20078) , pMRX-IPU-muGFP-OPTN (RDB20079) , pMRX-IPU-muGFP-Ubiquitin (RDB20080) , pMRX-IPU-muGFP-p62 (RDB20081) , pMRX-IPU-muGFP-NBR1 (RDB20082) , pMRX-IPU-muGFP-NDP52 (RDB20083) , pMRX-IPU-muGFP-TAX1BP1 (RDB20084) , HeLa(RCB0007) , 293T(RCB2202) Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates.
DNA material pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394) Transcriptional Fluctuations Govern the Serum-Dependent Cell Cycle Duration Heterogeneities in Mammalian Cells.