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  • Search Condition : Filter (MeSH = Sphingolipids / genetics)
Species Resource Title
DNA material pCDNA3-DEGS1 (RDB20900) , pCDNA3-DEGS2 (RDB20901) , pCDNA3-HygR (RDB20899) Loss of function and reduced levels of sphingolipid desaturase DEGS1 variants are both relevant in disease mechanism.
C.elegans tm1547 Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in C. elegans.
Yeast NBRP Yeast Regulation of sphingolipid biosynthesis in the endoplasmic reticulum via signals from the plasma membrane in budding yeast.
Human and Animal Cells CACO-2(RCB0988) Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph.
Human and Animal Cells IEC 6(RCB0993) Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases.
C.elegans RNAi-based biosynthetic pathway screens to identify in vivo functions of non-nucleic acid-based metabolites such as lipids.
DNA material pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394) , CSII-EF-MCS (RDB04378). Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein.
Human and Animal Cells B16 melanoma(RCB1283) , GM95(RCB1026) , Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.