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  • Search Condition : Filter (MeSH = Tumor Suppressor Proteins / metabolism)
Species Resource
INFORMATION Yeast A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.
Yeast The S. pombe genomic library A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.
C.elegans tm1615 Deleted in cancer 1 (DICE1) is an essential protein controlling the topology of the inner mitochondrial membrane in C. elegans.
C.elegans tm853 The nucleotide excision repair pathway is required for UV-C-induced apoptosis in Caenorhabditis elegans.
Drosophila Crossveinless-c, the Drosophila homolog of tumor suppressor DLC1, regulates directional elongation of dendritic branches via down-regulating Rho1 activity.
Drosophila UASactinGFP (UAS-actGFP) Nonmuscle Myosin II helps regulate synaptic vesicle mobility at the Drosophila neuromuscular junction.
Drosophila Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila.
Mice C57BL-p53+/- 6-mercaptopurine (6-MP) induces p53-mediated apoptosis of neural progenitor cells in the developing fetal rodent brain.
Yeast FY7448 A homeodomain transcription factor regulates the DNA replication checkpoint in yeast.
Zebrafish rw021(Tg(ath5:GFP)) ? , rw399? , RIKEN WT (RW) Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways.
Drosophila 7293R-1 Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites.
Drosophila In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2.
C.elegans Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans.
DNA material pEF6-FLAG-human IRAK1 (RDB16723) , pCDNA3-FLAG-human TRAF6 (RDB16722) , pEF6-Myc-mouse Optineurin (RDB16718) , pEF6-Myc-mouse Optineurin(E50K) (RDB16719) , pEF6-Myc-mouse Optineurin(D474N) (RDB16720) , pEF6-Myc-mouse Optineurin(H486R) (RDB16721) Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling.
C.elegans tm3976 Identification of a genetic interaction between the tumor suppressor EAF2 and the retinoblastoma protein (Rb) signaling pathway in C. elegans and prostate cancer cells.
C.elegans tm1086 Exploring the link between MORF4L1 and risk of breast cancer.
DNA material pLL3.7 K122 FH-TAZ-ires-GFP-TEAD-responsive-H2B mCherry (RDB13967) , pFLAG-human yes-associated protein (YAP)1 (RDB13968) , pClneoMyc-LATS1 (RDB13969) , pClneoMyc-LATS2 (RDB13970) , pClneoLuc-PP1A (RDB13971) , pClneoLuc-PP2A (RDB13972). A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells.
Drosophila Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture.
Medaka Hatching enzyme , d-rR/TOKYO (MT837) Loss of zinc finger MYND-type containing 10 (zmynd10) affects cilia integrity and axonemal localization of dynein arms, resulting in ciliary dysmotility, polycystic kidney and scoliosis in medaka (Oryzias latipes).
DNA material AxCANCre (RDB01748) The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage.