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  • Search Condition : Filter (MeSH = Ubiquitin-Protein Ligases* / metabolism)
Species Resource Title
C.elegans tm2321 Widespread destabilization of Caenorhabditis elegans microRNAs by the E3 ubiquitin ligase EBAX-1.
C.elegans tm6709 , tm1759 , tm5921 , tm6321 , tm10273 , tm2664 , tm662 HSP70 inhibits CHIP E3 ligase activity to maintain germline function in Caenorhabditis elegans.
C.elegans tm2692 , tm1779 Disease-associated mutations in C-terminus of HSP70 interacting protein (CHIP) impair its ability to negatively regulate mitophagy.
Human and Animal Cells Huh7(RCB1366) , Huh6(RCB1367) Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.
Mice RBRC01834 UBE3A controls axon initial segment in the cortical pyramidal neurons.
DNA material , Human and Animal Cells pMRX-IPU-muGFP-OPTN delta UBAN (RDB20078) , pMRX-IPU-muGFP-OPTN (RDB20079) , pMRX-IPU-muGFP-Ubiquitin (RDB20080) , pMRX-IPU-muGFP-p62 (RDB20081) , pMRX-IPU-muGFP-NBR1 (RDB20082) , pMRX-IPU-muGFP-NDP52 (RDB20083) , pMRX-IPU-muGFP-TAX1BP1 (RDB20084) , HeLa(RCB0007) , 293T(RCB2202) Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates.
DNA material pGL3-mUcp1Enhancer_MiniPromoter_Luciferase (RDB20463) , pGL3-mPgc1aEnhancer_MiniPromoter_Luciferase (RDB20464) , pGL3-mMtif2Promoter_Luciferase (RDB20465) Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates.
DNA material CSII-CMV-MCS-IRES2-Bsd (RDB04385) Polyubiquitinated PCNA triggers SLX4-mediated break-induced replication in alternative lengthening of telomeres (ALT) cancer cells.
DNA material CSII-CMV-MCS-IRES2-Bsd (RDB04385) , pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394) ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.
DNA material pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) CRL2KLHDC3 and CRL1Fbxw7 cooperatively mediate c-Myc degradation.
Mice RBRC09483 Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.
Drosophila Presynaptic Ube3a E3 ligase promotes synapse elimination through down-regulation of BMP signaling.
Yeast A positive genetic selection for transmembrane domain mutations in HRD1 underscores the importance of Hrd1 complex integrity during ERAD.
Drosophila DGRC#109654 Essential requirement for RING finger E3 ubiquitin ligase Hakai in early embryonic development of Drosophila.