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  • Search Condition : Filter (MeSH = Ubiquitin-Protein Ligases / genetics)
Species Resource Title
Drosophila 3016R-2 FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo.
C.elegans tm5615 , tmC18[tmIs1236] Ubiquitin ligases and a processive proteasome facilitate protein clearance during the oocyte-to-embryo transition in Caenorhabditis elegans.
C.elegans tm1108 Selective disruption of Drp1-independent mitophagy and mitolysosome trafficking by an Alzheimer's disease relevant tau modification in a novel Caenorhabditis elegans model.
C.elegans tm1779 Mitochondria-affecting small molecules ameliorate proteostasis defects associated with neurodegenerative diseases.
Human and Animal Cells 293T(RCB2202) FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.
Drosophila DGRC#109029 , HMS01352 , HMJ30245 , 5862R-1 A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila.
Lotus / Glycine Gifu B-129, MG-20 RPG interacts with E3-ligase CERBERUS to mediate rhizobial infection in Lotus japonicus
DNA material pMXs-IP-HA-Parkin (RDB19764) , pMXs-IP-GFP-Omp25 (RDB19786) Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane.
Arabidopsis / Cultured plant cells, genes rpd00105 Regulator of Awn Elongation 3, an E3 ubiquitin ligase, is responsible for loss of awns during African rice domestication.
Human and Animal Cells HeLa/Fucci(RCB2812) The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells.
Human and Animal Cells HUDEP-2(RCB4557) Activation of γ-globin expression by hypoxia-inducible factor 1α.
DNA material pClgn1.1-Trim41-PA-1D4 (RDB19656) Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice.
Human and Animal Cells PANC-1(RCB2095) PINK1-dependent and Parkin-independent mitophagy is involved in reprogramming of glycometabolism in pancreatic cancer cells.
Drosophila DGRC#110685 Par3 cooperates with Sanpodo for the assembly of Notch clusters following asymmetric division of Drosophila sensory organ precursor cells.
Zebrafish Tg(6xTcf/LefBS-miniP:d2EGFP) A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control.
Human and Animal Cells OP9(RCB1124) Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.
Human and Animal Cells K562(RCB0027) Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb.
Human and Animal Cells HuCCT1(RCB1960) FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells.
Human and Animal Cells DT40(RCB1464) Targeted siRNA Screens Identify ER-to-Mitochondrial Calcium Exchange in Autophagy and Mitophagy Responses in RPE1 Cells.