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  • Search Condition : Filter (MeSH = Ubiquitin-Protein Ligases / genetics)
Species Resource Title
Drosophila DGRC#110685 Par3 cooperates with Sanpodo for the assembly of Notch clusters following asymmetric division of Drosophila sensory organ precursor cells.
Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control.
Human and Animal Cells OP9(RCB1124) Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.
Human and Animal Cells K562 Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb.
Human and Animal Cells HuCCT1(RCB1960) FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells.
Human and Animal Cells DT40(RCB1464) Targeted siRNA Screens Identify ER-to-Mitochondrial Calcium Exchange in Autophagy and Mitophagy Responses in RPE1 Cells.
Human and Animal Cells HuH-7(RCB1366) Overexpression of WWP1 promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma.
Human and Animal Cells HEV0190 CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats.
Human and Animal Cells CHP-134(RCB0487) , NB9(RCB0477) , NB69(RCB0480) Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor.
Human and Animal Cells HuH-7(RCB1366) , Li-7(RCB1941) , Hep G2(RCB1648) MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma.
Human and Animal Cells MKN74(RCB1002) RNF126 as a Marker of Prognosis and Proliferation of Gastric Cancer.
Human and Animal Cells Vero(RCB0001) , HEp-2(RCB1889) Herpes simplex virus requires poly(ADP-ribose) polymerase activity for efficient replication and induces extracellular signal-related kinase-dependent phosphorylation and ICP0-dependent nuclear localization of tankyrase 1.
Human and Animal Cells TUHR4TKB(RCB1198) , TUHR10TKB(RCB1275) , TUHR14TKB(RCB1383) Hypermethylation of the RASSF1A tumor suppressor gene in Japanese clear cell renal cell carcinoma.
Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.
Zebrafish Tg(vglut2a:lRl-Gal4) Molecular and cellular determinants of motor asymmetry in zebrafish.
C.elegans tm1779 , tm598 , tm1133 , tm1108 Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration.
C.elegans tm1145 , tm1813 The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans.
Drosophila Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila.
DNA material Genome Network Project Human cDNA , IRAL021H13 (HGY088581) , IRAK004A12 (HGX001612) S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein.
Mice RBRC02759 Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency.