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  • Search Condition : Filter (MeSH = Ubiquitin-Protein Ligases / genetics)
Species Resource Title
Yeast BY23849 Role of the San1 ubiquitin ligase in the heat stress-induced degradation of nonnative Nup1 in the nuclear pore complex.
DNA material CSII-CMV-MCS-IRES2-Bsd (RDB04385) RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair.
Human and Animal Cells HeLa(RCB0007) Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics.
Human and Animal Cells 293T(RCB2202) E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3.
DNA material CSII-CMV-MCS-IRES2-Bsd (RDB04385) , pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control.
DNA material pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation.
DNA material CSII-EF-MCS-IRES2-hKO1 (RDB07915) , pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance.
Human and Animal Cells HCT116 Tet-OsTIR1(RCB4663) Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells.
Rice W0009, W1468 Regulator of Awn Elongation 3, an E3 ubiquitin ligase, is responsible for loss of awns during African rice domestication.
Drosophila 3016R-2 FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo.
C.elegans tm5615 , tmC18[tmIs1236] Ubiquitin ligases and a processive proteasome facilitate protein clearance during the oocyte-to-embryo transition in Caenorhabditis elegans.
C.elegans tm1108 Selective disruption of Drp1-independent mitophagy and mitolysosome trafficking by an Alzheimer's disease relevant tau modification in a novel Caenorhabditis elegans model.
C.elegans tm1779 Mitochondria-affecting small molecules ameliorate proteostasis defects associated with neurodegenerative diseases.
Human and Animal Cells 293T(RCB2202) , HeLa FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.
Drosophila DGRC#109029 , HMS01352 , HMJ30245 , 5862R-1 A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila.
Lotus / Glycine Gifu B-129, MG-20 RPG interacts with E3-ligase CERBERUS to mediate rhizobial infection in Lotus japonicus
DNA material pMXs-IP-HA-Parkin (RDB19764) , pMXs-IP-GFP-Omp25 (RDB19786) Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane.
Arabidopsis / Cultured plant cells, genes rpd00105 Regulator of Awn Elongation 3, an E3 ubiquitin ligase, is responsible for loss of awns during African rice domestication.
Human and Animal Cells HeLa/Fucci(RCB2812) The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells.
Human and Animal Cells HUDEP-2(RCB4557) Activation of γ-globin expression by hypoxia-inducible factor 1α.