RRC ID 48029
著者 Tohyama T, Kinoshita M, Kobayashi K, Isa K, Watanabe D, Kobayashi K, Liu M, Isa T.
タイトル Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys.
ジャーナル Proc Natl Acad Sci U S A
Abstract The direct cortico-motoneuronal connection is believed to be essential for the control of dexterous hand movements, such as precision grip in primates. It was reported, however, that even after lesion of the corticospinal tract (CST) at the C4-C5 segment, precision grip largely recovered within 1-3 mo, suggesting that the recovery depends on transmission through intercalated neurons rostral to the lesion, such as the propriospinal neurons (PNs) in the midcervical segments. To obtain direct evidence for the contribution of PNs to recovery after CST lesion, we applied a pathway-selective and reversible blocking method using double viral vectors to the PNs in six monkeys after CST lesions at C4-C5. In four monkeys that showed nearly full or partial recovery, transient blockade of PN transmission after recovery caused partial impairment of precision grip. In the other two monkeys, CST lesions were made under continuous blockade of PN transmission that outlasted the entire period of postoperative observation (3-4.5 mo). In these monkeys, precision grip recovery was not achieved. These results provide evidence for causal contribution of the PNs to recovery of hand dexterity after CST lesions; PN transmission is necessary for promoting the initial stage recovery; however, their contribution is only partial once the recovery is achieved.
巻・号 114(3)
ページ 604-609
公開日 2017-1-17
DOI 10.1073/pnas.1610787114
PII 1610787114
PMID 28049844
PMC PMC5255616
MeSH Animals Disease Models, Animal Female Genetic Vectors Green Fluorescent Proteins / genetics Hand / innervation Hand / physiopathology Hand Strength / physiology Interneurons / physiology Macaca Male Motor Neurons / physiology* Nerve Block Nerve Regeneration / physiology Spinal Cord Injuries / physiopathology* Synaptic Transmission / physiology
IF 9.412
引用数 30
WOS 分野 NEUROSCIENCES
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