論文 - 詳細
| RRC ID | 1 |
|---|---|
| 著者 | Tsuruyama T, Nakamura T, Jin G, Ozeki M, Yamada Y, Hiai H. |
| タイトル | Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
We found that the second intron of Stat5a was one of the common integration sites of the endogenous ecotropic murine leukemia virus, i.e., SL/Kh virus integration-1 (Svi1), in early pre-B lymphomas in SL/Kh mice. The high expression of STAT5A induced by Svi1 integration and activation accelerated the transcription of its target genes such as c-Myc. Transfection of the constitutively active Stat5a mutant cDNA, but not of the wild-type cDNA, to the bone marrow cells induced colony formation of pre-B cells in a methylcellulose medium and escaped from dependence on IL-7. Such growth depended on a genetic factor in the SL/Kh strain. Consitutively high expression of Stat5a either by retrovirus integration or transfection of active mutant cDNA can be lymphomagenic to early pre-B cells in collaboration with a certain genetic background factor of mice. |
| 巻・号 | 99(12) |
| ページ | 8253-8 |
| 公開日 | 2002-6-11 |
| DOI | 10.1073/pnas.112202899 |
| PII | 112202899 |
| PMID | 12048235 |
| PMC | PMC123054 |
| MeSH | 3' Untranslated Regions / genetics Animals Base Sequence Bone Marrow Cells / cytology Bone Marrow Cells / pathology Cell Division DNA Primers DNA-Binding Proteins / genetics* Exons Genes, myc Introns Leukemia Virus, Murine / genetics* Lymphoma, B-Cell / genetics* Lymphoma, B-Cell / virology Mice Mice, Inbred Strains Milk Proteins* Phenotype Reverse Transcriptase Polymerase Chain Reaction STAT5 Transcription Factor Trans-Activators / genetics* Transfection Virus Integration* |
| IF | 9.412 |
| 引用数 | 32 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00222 |