Reference - Detail
| RRC ID | 1020 |
|---|---|
| Author | Long TT, Nakazawa S, Onizuka S, Huaman MC, Kanbara H. |
| Title | Influence of CD4+CD25+ T cells on Plasmodium berghei NK65 infection in BALB/c mice. |
| Journal | Int J Parasitol |
| Abstract |
CD4(+) T cells co-expressing CD25 (CD4(+)CD25(+) T cells) have been identified as immunoregulatory suppressors modulating autoimmune response. Beside that, autoimmune response was supposed to be associated with malaria infection. Based on these data, we hypothesised that CD4(+)CD25(+) T cells may influence protective immunity to malaria parasites, while suppressing autoimmune response arising throughout the course of malarial infection. To test this possibility, we evaluated the kinetics of CD4(+)CD25(+) T cells during malaria infection and investigated the influence of CD25 depletion by anti-mouse CD25 monoclonal antibody (PC61) on the infection, using a mouse model of premunition to Plasmodium berghei NK65 malaria. The results showed that, during exacerbation of P. berghei NK65 infection, the proportion of CD4(+)CD25(+) T cells among CD4(+) T cells decreased, although that of CD4(+) T cells increased. CD25 depletion clearly delayed the growth of parasitaemia during parasite challenge, particularly in immunised mice. These findings demonstrated that CD4(+)CD25(+) T cells are able to influence protective immunity underlying premunition to P. berghei NK65 parasites. |
| Volume | 33(2) |
| Pages | 175-83 |
| Published | 2003-2-1 |
| DOI | 10.1016/s0020-7519(02)00261-8 |
| PII | S0020751902002618 |
| PMID | 12633655 |
| MeSH | Animals Antigens, Protozoan / immunology Autoimmunity CD4 Antigens / immunology* CD4 Lymphocyte Count CD4-Positive T-Lymphocytes / immunology* Female Immunization Malaria / immunology* Malaria / prevention & control Mice Mice, Inbred BALB C Models, Animal Plasmodium berghei / immunology* Receptors, Interleukin-2 / immunology* |
| IF | 3.53 |
| Times Cited | 70 |
| WOS Category | PARASITOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic microorganisms | Plasmodium berghei NK65? |