RRC ID |
1030
|
Author |
Kawamura Y, Fujiwara H, Mishima N, Tanaka Y, Tanimoto A, Ikawa S, Itoh Y, Ezaki T.
|
Title |
First Streptococcus agalactiae isolates highly resistant to quinolones, with point mutations in gyrA and parC.
|
Journal |
Antimicrob Agents Chemother
|
Abstract |
Three isolates of Streptococcus agalactiae highly resistant to multiple fluoroquinolones were isolated in Japan. Compared with susceptible strains of S. agalactiae, these quinolone-resistant strains had double point mutations within the quinolone resistance-determining regions of gyrA and parC; Ser-81 was changed to Leu (TCA --> TTA) in the amino acid sequence deduced from gyrA, and Ser-79 was changed to Phe (TCC --> TTC) in the amino acid sequence deduced from parC. Comparative sequence analysis revealed the possibility of gene transfer between S. agalactiae and another beta-hemolytic streptococcus, Streptococcus difficile.
|
Volume |
47(11)
|
Pages |
3605-9
|
Published |
2003-11-1
|
DOI |
10.1128/AAC.47.11.3605-3609.2003
|
PMID |
14576126
|
PMC |
PMC253773
|
MeSH |
Aged
Amino Acid Sequence
Amino Acid Substitution
Anti-Infective Agents / pharmacology*
DNA Gyrase / genetics*
DNA Topoisomerase IV / genetics*
Drug Resistance, Bacterial / genetics
Female
Gene Transfer, Horizontal
Humans
Infant, Newborn
Male
Molecular Sequence Data
Point Mutation / genetics*
Quinolones / pharmacology*
Streptococcal Infections / microbiology
Streptococcus agalactiae / drug effects*
Streptococcus agalactiae / genetics*
|
IF |
4.904
|
Times Cited |
60
|
WOS Category
|
PHARMACOLOGY & PHARMACY
MICROBIOLOGY
|
Resource |
Pathogenic microorganisms |
GTC 1966
GTC 1967
GTC 2001
GTC 1234
GTC 262
GTC 269
GTC 542
GTC 244
GTC 423?
GTC 431
GTC 842
GTC 543?
GTC 730
GTC 268?
GTC 216
GTC 221 |