論文 - 詳細
| RRC ID | 104 |
|---|---|
| 著者 | Negishi H, Xu JW, Ikeda K, Njelekela M, Nara Y, Yamori Y. |
| タイトル | Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats. |
| ジャーナル | J Nutr |
| Abstract |
Oxidative stress was reported to be involved not only in cardiovascular diseases, but also in hypertension. Epidemiologic studies indicated that tea consumption slightly reduces blood pressure. We conducted two studies to determine whether black and green tea can lower blood pressure (BP) in stroke-prone spontaneously hypertensive rats (SHRSP). Male SHRSP (n=15) were allowed to recover for 2 wk after a transmitter for measuring BP was implanted in the peritoneal cavity. The rats were divided into three groups: the control group consumed tap water (30 mL/d); the black tea polyphenol group (BTP) consumed water containing 3.5 g/L thearubigins, 0.6 g/L theaflavins, 0.5 g/L flavonols and 0.4 g/L catechins; and the green tea polyphenol group (GTP) consumed water containing 3.5 g/L catechins, 0.5 g/L flavonols and 1 g/L polymetric flavonoids. The telemetry system was used to measure BP, which were recorded continuously every 5 min for 24 h. During the daytime, systolic and diastolic BP were significantly lower in the BTP and GTP groups than in the controls. Protein expressions of catalase and phosphorylated myosin light chain (MLC-p) were measured in the aorta by Western blotting. GTP significantly increased catalase expression, and BTP and GTP significantly decreased MLC-p expression in the aorta. These data demonstrate that both black and green tea polyphenols attenuate blood pressure increases through their antioxidant properties in SHRSP. Furthermore, because the amounts of polyphenols used in this experiment correspond to those in approximately 1 L of tea, the regular consumption of black and green tea may also provide some protection against hypertension in humans. |
| 巻・号 | 134(1) |
| ページ | 38-42 |
| 公開日 | 2004-1-1 |
| DOI | 10.1093/jn/134.1.38 |
| PMID | 14704290 |
| MeSH | Animals Antioxidants / administration & dosage* Aorta / chemistry Blood Pressure / drug effects* Catalase / analysis Catechin / blood Flavonoids / administration & dosage* Hypertension / drug therapy* Male Myosin Light Chains / analysis Nitric Oxide / blood Nitric Oxide / urine Phenols / administration & dosage* Phosphorylation Polyphenols Rats Rats, Inbred SHR Stroke / prevention & control Tea / chemistry* |
| IF | 4.281 |
| 引用数 | 194 |
| WOS 分野 | NUTRITION & DIETETICS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ラット | SHRSP/Izm(strainID=409) |