論文 - 詳細
| RRC ID | 1051 |
|---|---|
| 著者 | Komatsu K, Tsuda M, Tanaka Y, Mikami Y, Kobayashi J. |
| タイトル | Absolute stereochemistry of immunosuppressive macrolide brasilinolide A and its new congener brasilinolide C. |
| ジャーナル | J Org Chem |
| Abstract |
Brasilinolide A (2) is a 32-membered polyhydroxyl macrolide with immunosuppressive activity isolated from a pathogenic actinomycete, Nocardia brasiliensis IFM0406. The absolute configurations at 26 chiral centers of 2 and its new congener, brasilinolide C (1), were determined on the basis of the spectral data of 1 and degradation products derived from 1 and 2. |
| 巻・号 | 69(5) |
| ページ | 1535-41 |
| 公開日 | 2004-3-5 |
| DOI | 10.1021/jo035773v |
| PMID | 14987008 |
| MeSH | Carbohydrate Conformation Hydrolysis Immunosuppressive Agents / chemistry* Immunosuppressive Agents / isolation & purification Macrolides / chemistry* Macrolides / isolation & purification Magnetic Resonance Spectroscopy Molecular Structure Nocardia / metabolism* Oxidation-Reduction Pyrans / chemistry* Pyrans / isolation & purification Stereoisomerism |
| IF | 4.335 |
| 引用数 | 24 |
| WOS 分野 | CHEMISTRY, ORGANIC |
| リソース情報 | |
| 病原微生物 | IFM 0406 |