論文 - 詳細
| RRC ID | 1052 |
|---|---|
| 著者 | Harada K, Tomita K, Fujii K, Masuda K, Mikami Y, Yazawa K, Komaki H. |
| タイトル | Isolation and structural characterization of siderophores, madurastatins, produced by a pathogenic Actinomadura madurae. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
Madurastatins Al (1), A2 (2) and A3 (3), novel pentapeptides that were acylated with salicylic acid at the N-terminus, were isolated from the culture broth of a pathogenic Actinomadura madurae IFM 0745 strain. These structures were mainly determined by 2D NMR and MS/MS spectral techniques. The strain produced simultaneously madurastatins B1 (4) and B2 (5) consisting of Ser and salicylic acid moieties. Compounds 1 and 4 had an antibacterial activity against Micrococcus luteus, indicating that the presence of the aziridine ring is essential for such activity. Because 1 has a strong affinity with ferric ion due to the presence of two hydroxamic acids and a salicylic acid, it is considered to be a siderophore that is a low molecular weight iron chelater. The production of siderophores may be one of the characteristics of pathogenic microorganisms. |
| 巻・号 | 57(2) |
| ページ | 125-35 |
| 公開日 | 2004-2-1 |
| DOI | 10.7164/antibiotics.57.125 |
| PMID | 15112961 |
| MeSH | Actinobacteria / classification Actinobacteria / metabolism* Anti-Bacterial Agents / biosynthesis Anti-Bacterial Agents / chemistry* Anti-Bacterial Agents / isolation & purification* Chemical Phenomena Chemistry, Physical Chromatography, High Pressure Liquid Fermentation Ferric Compounds / chemistry Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Molecular Conformation Molecular Weight Oligopeptides / biosynthesis Oligopeptides / chemistry* Oligopeptides / isolation & purification* Salicylates / chemistry* Salicylates / isolation & purification* Salicylates / metabolism Spectrometry, Mass, Electrospray Ionization Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Ultraviolet |
| IF | 2.668 |
| 引用数 | 31 |
| WOS 分野 | PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原微生物 | IFM 0745 |