| RRC ID |
1052
|
| 著者 |
Harada K, Tomita K, Fujii K, Masuda K, Mikami Y, Yazawa K, Komaki H.
|
| タイトル |
Isolation and structural characterization of siderophores, madurastatins, produced by a pathogenic Actinomadura madurae.
|
| ジャーナル |
J Antibiot (Tokyo)
|
| Abstract |
Madurastatins Al (1), A2 (2) and A3 (3), novel pentapeptides that were acylated with salicylic acid at the N-terminus, were isolated from the culture broth of a pathogenic Actinomadura madurae IFM 0745 strain. These structures were mainly determined by 2D NMR and MS/MS spectral techniques. The strain produced simultaneously madurastatins B1 (4) and B2 (5) consisting of Ser and salicylic acid moieties. Compounds 1 and 4 had an antibacterial activity against Micrococcus luteus, indicating that the presence of the aziridine ring is essential for such activity. Because 1 has a strong affinity with ferric ion due to the presence of two hydroxamic acids and a salicylic acid, it is considered to be a siderophore that is a low molecular weight iron chelater. The production of siderophores may be one of the characteristics of pathogenic microorganisms.
|
| 巻・号 |
57(2)
|
| ページ |
125-35
|
| 公開日 |
2004-2-1
|
| DOI |
10.7164/antibiotics.57.125
|
| PMID |
15112961
|
| MeSH |
Actinobacteria / classification
Actinobacteria / metabolism*
Anti-Bacterial Agents / biosynthesis
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / isolation & purification*
Chemical Phenomena
Chemistry, Physical
Chromatography, High Pressure Liquid
Fermentation
Ferric Compounds / chemistry
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Conformation
Molecular Weight
Oligopeptides / biosynthesis
Oligopeptides / chemistry*
Oligopeptides / isolation & purification*
Salicylates / chemistry*
Salicylates / isolation & purification*
Salicylates / metabolism
Spectrometry, Mass, Electrospray Ionization
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Ultraviolet
|
| IF |
2.668
|
| 引用数 |
31
|
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
IMMUNOLOGY
MICROBIOLOGY
|
| リソース情報 |
| 病原微生物 |
IFM 0745 |
