| RRC ID |
1059
|
| Author |
Melkusová S, Bujdáková H, Volleková A, Myoken Y, Mikami Y.
|
| Title |
The efficiency of the benzothiazole APB, the echinocandin micafungin, and amphotericin B in fluconazole-resistant Candida albicans and Candida dubliniensis.
|
| Journal |
Pharmazie
|
| Abstract |
This study presents the efficiency of the experimental antifungal agents 6-amino-2-n-pentylthiobenzothiazole (APB) and the echinocandin micafungin, and amphotericin B against fluconazole-resistant Candida albicans and Candida dubliniensis (MIC95 for fluconazole > 64 mg/l). The benzothiazole APB was less active against C. albicans and C. dubliniensis (MIC80 = 8 - 32 mg/l, MIC95 = 16 - 64 mg/l) than amphotericin B, which was efficient in a concentration range from 0.125 to 2 mg/l. However, the efficiency of micafungin was very high with MIC80, and MIC100 < or = 0.031 mg/l.
|
| Volume |
59(7)
|
| Pages |
573-4
|
| Published |
2004-7-1
|
| PMID |
15296100
|
| MeSH |
Amphotericin B / pharmacology*
Antifungal Agents / pharmacology*
Candida / drug effects*
Candida albicans / drug effects*
Candidiasis / microbiology
Drug Resistance, Fungal
Echinocandins
Fluconazole / pharmacology*
Humans
Lipopeptides
Lipoproteins / pharmacology*
Micafungin
Microbial Sensitivity Tests
Peptides, Cyclic / pharmacology*
Thiazoles / pharmacology*
|
| IF |
1.198
|
| Times Cited |
9
|
|
WOS Category
|
CHEMISTRY, MULTIDISCIPLINARY
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
|
| Resource |
| Pathogenic microorganisms |
IFM 48313
IFM 49832
IFM 51757
IFM 52112 |
