| RRC ID |
1064
|
| 著者 |
Komatsu K, Tsuda M, Shiro M, Tanaka Y, Mikami Y, Kobayashi J.
|
| タイトル |
Brasilicardins B-D, new tricyclic terpenoids [correction of terpernoids] from actinomycete Nocardia brasiliensis.
|
| ジャーナル |
Bioorg Med Chem
|
| Abstract |
Three new tricyclic terpenoids, brasilicardins B-D (2-4), were isolated together with brasilicardin A (1), a potent immunosuppressive compound, from the cultured broth of a pathogenic actinomycete Nocardia brasiliensis IFM0406, and the structures and stereochemistry were determined by spectroscopic data and a single crystal X-ray diffraction analysis. The immunosuppressive and cytotoxic activities of 2-4 were examined in the comparison with 1.
|
| 巻・号 |
12(21)
|
| ページ |
5545-51
|
| 公開日 |
2004-11-1
|
| DOI |
10.1016/j.bmc.2004.08.007
|
| PII |
S0968-0896(04)00610-8
|
| PMID |
15465331
|
| MeSH |
Aminoglycosides / chemistry*
Aminoglycosides / isolation & purification*
Aminoglycosides / pharmacology
Animals
Cyclization
Cytotoxins / chemistry
Cytotoxins / isolation & purification
Cytotoxins / pharmacology
Female
Immunosuppressive Agents / chemistry
Immunosuppressive Agents / isolation & purification
Immunosuppressive Agents / pharmacology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Nocardia / chemistry*
Terpenes / chemistry*
Terpenes / isolation & purification*
Terpenes / pharmacology
|
| IF |
3.073
|
| 引用数 |
21
|
|
WOS 分野
|
CHEMISTRY, ORGANIC
CHEMISTRY, MEDICINAL
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| 病原微生物 |
IFM 0406 |
