RRC ID 1064
Author Komatsu K, Tsuda M, Shiro M, Tanaka Y, Mikami Y, Kobayashi J.
Title Brasilicardins B-D, new tricyclic terpenoids [correction of terpernoids] from actinomycete Nocardia brasiliensis.
Journal Bioorg Med Chem
Abstract Three new tricyclic terpenoids, brasilicardins B-D (2-4), were isolated together with brasilicardin A (1), a potent immunosuppressive compound, from the cultured broth of a pathogenic actinomycete Nocardia brasiliensis IFM0406, and the structures and stereochemistry were determined by spectroscopic data and a single crystal X-ray diffraction analysis. The immunosuppressive and cytotoxic activities of 2-4 were examined in the comparison with 1.
Volume 12(21)
Pages 5545-51
Published 2004-11-1
DOI 10.1016/j.bmc.2004.08.007
PII S0968-0896(04)00610-8
PMID 15465331
MeSH Aminoglycosides / chemistry* Aminoglycosides / isolation & purification* Aminoglycosides / pharmacology Animals Cyclization Cytotoxins / chemistry Cytotoxins / isolation & purification Cytotoxins / pharmacology Female Immunosuppressive Agents / chemistry Immunosuppressive Agents / isolation & purification Immunosuppressive Agents / pharmacology Mice Mice, Inbred BALB C Mice, Inbred C57BL Nocardia / chemistry* Terpenes / chemistry* Terpenes / isolation & purification* Terpenes / pharmacology
IF 2.802
Times Cited 21
WOS Category CHEMISTRY, ORGANIC CHEMISTRY, MEDICINAL BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
Pathogenic microorganisms IFM 0406