| RRC ID |
1066
|
| Author |
Hoshino Y, Mukai A, Yazawa K, Uno J, Ishikawa J, Ando A, Fukai T, Mikami Y.
|
| Title |
Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. I. Taxonomy, fermentation, isolation and biological activities.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
A new thiazolidine-type antibiotic with zinc in its structure, designated transvalencin A, was isolated from Nocardia sp. IFM 10065, a clinical isolate from a patient with actinomycotic mycetoma. The strain was identified as Nocardia transvalensis based on its morphological, phenotypic and phylogenetic characteristics. Transvalencin A showed antimicrobial activity against fungi such as Trichophyton mentagrophytes and Cryptococcus neoformans. The antibiotic is also active against Gram-positive bacteria such as Micrococcus luteus. We observed higher activity for fungi in an acidic medium than in a neutral medium.
|
| Volume |
57(12)
|
| Pages |
797-802
|
| Published |
2004-12-1
|
| DOI |
10.7164/antibiotics.57.797
|
| PMID |
15745114
|
| MeSH |
Anti-Bacterial Agents* / isolation & purification
Anti-Bacterial Agents* / pharmacology
Fermentation
Microscopy, Electron, Scanning
Nocardia / chemistry*
Nocardia / classification
Nocardia / ultrastructure
Organometallic Compounds* / isolation & purification
Organometallic Compounds* / pharmacology
Phylogeny
Thiazoles* / isolation & purification
Thiazoles* / pharmacology
Zinc / chemistry*
|
| IF |
2.668
|
| Times Cited |
17
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
IMMUNOLOGY
MICROBIOLOGY
|
| Resource |
| Pathogenic microorganisms |
IFM 0092
IFM 0245
IFM 0265
IFM 0330
IFM 5368
IFM 10065
IFM 10489
IFM 40213
IFM 40215
IFM 40913
IFM 40913
IFM 10489 |
