| RRC ID |
1067
|
| Author |
Hoshino Y, Mukai A, Yazawa K, Uno J, Ando A, Mikami Y, Fukai T, Ishikawa J, Yamaguchi K.
|
| Title |
Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. II. Structure elucidation.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
A novel antifungal antibiotic, transvalencin A, is produced by Nocardia transvalensis IFM 10065 isolated from a patient with actinomycotic mycetoma in Japan. The antibiotic structure was elucidated using NMR, mass spectrometric investigations, and X-ray crystallographic analysis. Transvalencin A is a 1:1 complex of a zinc and an organic acid with a phenolic substituent. Transvalencin A is comprised of o-substituted p-chlorophenol, tetrasubstituted oxazoline, disubstituted thiazolyl-N-methylthiazolidine and monosubstituted N-methylthiazolidine.
|
| Volume |
57(12)
|
| Pages |
803-7
|
| Published |
2004-12-1
|
| DOI |
10.7164/antibiotics.57.803
|
| PMID |
15745115
|
| MeSH |
Anti-Bacterial Agents / chemistry*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Models, Molecular
Molecular Structure
Nocardia / chemistry*
Organometallic Compounds / chemistry*
Thiazoles / chemistry*
Zinc / chemistry*
|
| IF |
2.668
|
| Times Cited |
11
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
IMMUNOLOGY
MICROBIOLOGY
|
| Resource |
| Pathogenic microorganisms |
IFM 10065 |
