論文 - 詳細
| RRC ID | 10757 |
|---|---|
| 著者 | Awale S, Miyamoto T, Linn TZ, Li F, Win NN, Tezuka Y, Esumi H, Kadota S. |
| タイトル | Cytotoxic constituents of Soymida febrifuga from Myanmar. |
| ジャーナル | J Nat Prod |
| Abstract |
The 70% ethanol extract of Soymida febrifuga was found to kill PANC-1 human pancreatic cancer cells preferentially under nutrition-deprived conditions at a concentration of 10 microg/mL. Phytochemical investigation led to the isolation of 27 compounds including four new compounds [(3R)-6,4'-dihydroxy-8-methoxyhomoisoflavan (1), (2R)-7,4'-dihydroxy-5-methoxy-8-methylflavan (2), 7-hydroxy-6-methoxy-3-(4'-hydroxybenzyl)coumarin (3), and 6-hydroxy-7-methoxy-3-(4'-hydroxybenzyl)coumarin (4)]. 2',4'-Dihydroxychalcone (8) displayed the most potent preferential cytotoxicity (PC(50) 19.0 microM) against PANC-1 cells. In addition, the cytotoxic activity against colon 26-L5 carcinoma (colon 26-L5), B16-BL6 melanoma (B16-BL6), lung A549 adenocarcinoma (A549), cervix HeLa adenocarcinoma (HeLa), and HT-1080 fibrosarcoma (HT-1080) cell lines and their structure-activity relationship are discussed. The cytotoxic activity of 4'-hydroxy-3,5-dimethoxystilbene (6) against colon 26-L5 (IC(50) 2.96 microM) was found to be stronger than the positive control, doxorubicin, at IC(50) 3.12 microM. |
| 巻・号 | 72(9) |
| ページ | 1631-6 |
| 公開日 | 2009-9-1 |
| DOI | 10.1021/np9003323 |
| PMID | 19689125 |
| MeSH | Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification* Antineoplastic Agents, Phytogenic / pharmacology* Coumarins / chemistry Coumarins / isolation & purification* Coumarins / pharmacology* Doxorubicin / pharmacology Drug Screening Assays, Antitumor Female HeLa Cells Humans Isoflavones / chemistry Isoflavones / isolation & purification* Isoflavones / pharmacology* Molecular Structure Myanmar Plant Bark / chemistry Stereoisomerism Stilbenes / chemistry Stilbenes / isolation & purification* Stilbenes / pharmacology* Structure-Activity Relationship |
| IF | 3.782 |
| 引用数 | 27 |
| WOS 分野 | PHARMACOLOGY & PHARMACY PLANT SCIENCES CHEMISTRY, MEDICINAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) HeLa(RCB0007) |