RRC ID 10768
Author Tominaga K, Kagata T, Johmura Y, Hishida T, Nishizuka M, Imagawa M.
Title SLC39A14, a LZT protein, is induced in adipogenesis and transports zinc.
Journal FEBS J
Abstract During adipocyte differentiation, there is an underlying complex series of gene expressions. We have previously isolated many genes whose expression levels are quickly elevated by the addition of inducers to mouse 3T3-L1 preadipocyte cells. Here we report the isolation and characterization of SLC39A14, a member of the LZT proteins, one of the subfamilies of ZIP transporters. The expression of the SLC39A14 gene was strongly and rapidly induced at the early stages of differentiation. Moreover, it was highly restricted to the potential differentiation state of 3T3-L1 cells and the expression level was quite low in the nonadipogenic NIH-3T3 cells, indicating a dominant expression in adipocyte differentiation. The zinc uptake assay revealed that SLC39A14 functions as a zinc transporter. Taken together, these results suggest that SLC39A14 plays a role as a zinc transporter during the early stages of adipogenesis.
Volume 272(7)
Pages 1590-9
Published 2005-4-1
DOI 10.1111/j.1742-4658.2005.04580.x
PMID 15794747
MeSH Adipose Tissue / cytology Adipose Tissue / metabolism* Animals Cation Transport Proteins / genetics* Cation Transport Proteins / metabolism Cell Differentiation / physiology Cloning, Molecular Gene Expression Profiling Mice Zinc / metabolism*
IF 4.392
Times Cited 38
Human and Animal Cells K562 (RCB0027)