| RRC ID |
10806
|
| 著者 |
Iida T, Shiba H, Misawa T, Ohashi T, Eto Y, Yanaga K.
|
| タイトル |
Adenovirus-mediated CD40L gene therapy induced both humoral and cellular immunity against rat model of hepatocellular carcinoma.
|
| ジャーナル |
Cancer Sci
|
| Abstract |
Adenoviral-vector expressing CD40L (AxCAmCD40L)-mediated gene therapy was studied for treatment of hepatocellular carcinoma (HCC) using CD40 ligand (CD40L) complementary DNA in rats. The particular focus was whether humoral immunity took part in antitumor effect. When tumor cells transduced by AxCAmCD40L were implanted into the subcutaneous tissues of syngeneic rats, the tumor growth was suppressed. Intratumoral injection of AxCAmCD40L to pre-existing tumor in rats also led to significant reduction of tumor size. When tumor cells were re-implanted to prevention model rats and treatment model rats, no tumor growth was observed. Many studies to date have reported that cellular immunity induces antitumor immunity. However, the present study demonstrated that not only cellular immunity but also humoral immunity plays an essential role in a HCC model. These observations suggested that CD40L-mediated immune gene therapy for HCC was very effective treatment by activation of both cellular and humoral immune system.
|
| 巻・号 |
99(10)
|
| ページ |
2097-103
|
| 公開日 |
2008-10-1
|
| DOI |
10.1111/j.1349-7006.2008.00953.x
|
| PII |
CAS953
|
| PMID |
19016771
|
| MeSH |
Adenoviridae / genetics*
Animals
Antibody Formation
CD40 Ligand / genetics*
CD40 Ligand / immunology
Carcinoma, Hepatocellular / genetics
Carcinoma, Hepatocellular / immunology
Carcinoma, Hepatocellular / therapy*
Cell Line, Tumor
Disease Models, Animal
Gene Transfer Techniques
Genetic Therapy / methods*
Genetic Vectors
Immunity, Cellular
Liver Neoplasms, Experimental / genetics
Liver Neoplasms, Experimental / immunology
Liver Neoplasms, Experimental / prevention & control*
Rats
Rats, Inbred BUF
Survival Analysis
Tumor Burden
Xenograft Model Antitumor Assays
|
| IF |
4.966
|
| 引用数 |
8
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
RCN-9(RCB0511) |
