論文 - 詳細
| RRC ID | 10806 |
|---|---|
| 著者 | Iida T, Shiba H, Misawa T, Ohashi T, Eto Y, Yanaga K. |
| タイトル | Adenovirus-mediated CD40L gene therapy induced both humoral and cellular immunity against rat model of hepatocellular carcinoma. |
| ジャーナル | Cancer Sci |
| Abstract |
Adenoviral-vector expressing CD40L (AxCAmCD40L)-mediated gene therapy was studied for treatment of hepatocellular carcinoma (HCC) using CD40 ligand (CD40L) complementary DNA in rats. The particular focus was whether humoral immunity took part in antitumor effect. When tumor cells transduced by AxCAmCD40L were implanted into the subcutaneous tissues of syngeneic rats, the tumor growth was suppressed. Intratumoral injection of AxCAmCD40L to pre-existing tumor in rats also led to significant reduction of tumor size. When tumor cells were re-implanted to prevention model rats and treatment model rats, no tumor growth was observed. Many studies to date have reported that cellular immunity induces antitumor immunity. However, the present study demonstrated that not only cellular immunity but also humoral immunity plays an essential role in a HCC model. These observations suggested that CD40L-mediated immune gene therapy for HCC was very effective treatment by activation of both cellular and humoral immune system. |
| 巻・号 | 99(10) |
| ページ | 2097-103 |
| 公開日 | 2008-10-1 |
| DOI | 10.1111/j.1349-7006.2008.00953.x |
| PII | CAS953 |
| PMID | 19016771 |
| MeSH | Adenoviridae / genetics* Animals Antibody Formation CD40 Ligand / genetics* CD40 Ligand / immunology Carcinoma, Hepatocellular / genetics Carcinoma, Hepatocellular / immunology Carcinoma, Hepatocellular / therapy* Cell Line, Tumor Disease Models, Animal Gene Transfer Techniques Genetic Therapy / methods* Genetic Vectors Immunity, Cellular Liver Neoplasms, Experimental / genetics Liver Neoplasms, Experimental / immunology Liver Neoplasms, Experimental / prevention & control* Rats Rats, Inbred BUF Survival Analysis Tumor Burden Xenograft Model Antitumor Assays |
| IF | 4.966 |
| 引用数 | 8 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RCN-9(RCB0511) |