RRC ID 10913
Author Ariyasu T, Matsumoto S, Kyono F, Hanaya T, Arai S, Ikeda M, Kurimoto M.
Title Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose.
Journal In Vitro Cell. Dev. Biol. Anim.
Abstract Recently, a sweet taste receptor family, the T1R family, that recognizes some carbohydrates including sucrose was identified. Although the T1R3 molecule is known to participate in heterodimers that are used as sweet- and umami-tasting receptors, there is no evidence that T1R3 alone recognizes similar ligands. We demonstrate for the first time that the candidate sweet taste receptor T1R3 is essential for the recognition and response to the disaccharide trehalose. Our system is a valuable tool not only for understanding the relationship between sweeteners and their receptors but also for exploring the diversities of their receptors, resulting in the design of new high-potency sweeteners.
Volume 39(1-2)
Pages 80-8
Published 2003-1
DOI 10.1290/1543-706X(2003)039<0080:TRTIAE>2.0.CO;2
PII 0302013
PMID 12892531
MeSH Animals Calcium / metabolism Cell Line Humans Ionomycin / metabolism Ionophores / metabolism Ligands Mice Mice, Inbred C57BL Receptors, Cell Surface / genetics Receptors, Cell Surface / metabolism* Receptors, G-Protein-Coupled Recombinant Fusion Proteins / genetics Recombinant Fusion Proteins / metabolism Sucrose / metabolism Sweetening Agents / metabolism* Taste / physiology* Trehalose / metabolism*
IF 1.447
Times Cited 12
Human and Animal Cells 293 (RCB1637)