| RRC ID |
10913
|
| 著者 |
Ariyasu T, Matsumoto S, Kyono F, Hanaya T, Arai S, Ikeda M, Kurimoto M.
|
| タイトル |
Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose.
|
| ジャーナル |
In Vitro Cell Dev Biol Anim
|
| Abstract |
Recently, a sweet taste receptor family, the T1R family, that recognizes some carbohydrates including sucrose was identified. Although the T1R3 molecule is known to participate in heterodimers that are used as sweet- and umami-tasting receptors, there is no evidence that T1R3 alone recognizes similar ligands. We demonstrate for the first time that the candidate sweet taste receptor T1R3 is essential for the recognition and response to the disaccharide trehalose. Our system is a valuable tool not only for understanding the relationship between sweeteners and their receptors but also for exploring the diversities of their receptors, resulting in the design of new high-potency sweeteners.
|
| 巻・号 |
39(1-2)
|
| ページ |
80-8
|
| 公開日 |
2003-1-1
|
| DOI |
10.1290/1543-706X(2003)039<0080:TRTIAE>2.0.CO;2
|
| PII |
0302013
|
| PMID |
12892531
|
| MeSH |
Animals
Calcium / metabolism
Cell Line
Humans
Ionomycin / metabolism
Ionophores / metabolism
Ligands
Mice
Mice, Inbred C57BL
Receptors, Cell Surface / genetics
Receptors, Cell Surface / metabolism*
Receptors, G-Protein-Coupled
Recombinant Fusion Proteins / genetics
Recombinant Fusion Proteins / metabolism
Sucrose / metabolism
Sweetening Agents / metabolism*
Taste / physiology*
Trehalose / metabolism*
|
| IF |
1.665
|
| 引用数 |
14
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
293(RCB1637) |
