RRC ID 10948
著者 Kitano T, Tian W, Umetsu K, Yuasa I, Yamazaki K, Saitou N, Osawa M.
タイトル Origin and evolution of gene for prolactin-induced protein.
ジャーナル Gene
Abstract Prolactin-induced protein (PIP) is a small protein secreted into the fluid in several glands. We determined the PIP coding sequences of 5 hominoid species and estimated the numbers of synonymous and nonsynonymous substitutions for each branch of the mammalian PIP gene tree. The branch connecting hominoids and Old World monkeys showed significantly higher nonsynonymous than synonymous substitutions. These changes tended to be accumulated in the fibronectin-binding domain. Many other primate branches also showed higher nonsynonymous than synonymous substitutions, thus suggesting that the PIP genes of primates have experienced some kind of positive selection. We also considered the phylogenetic relationship of the PIP gene with the alpha-2-macroglobulin gene family. The results indicate that the PIP gene arose by partial gene duplication from a member of the alpha-2-macroglobulin gene family after the divergence between amphibians and other tetrapods.
巻・号 383
ページ 64-70
公開日 2006-11-15
DOI 10.1016/j.gene.2006.07.014
PII S0378-1119(06)00464-1
PMID 16949771
MeSH Amino Acid Sequence Amino Acid Substitution Animals Carrier Proteins / genetics* DNA / genetics Evolution, Molecular* Glycoproteins / genetics* Humans Membrane Transport Proteins Molecular Sequence Data Multigene Family Phylogeny Primates / genetics* Sequence Homology, Amino Acid Species Specificity alpha-Macroglobulins / genetics
IF 2.984
引用数 8
WOS 分野 GENETICS & HEREDITY
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