論文 - 詳細
| RRC ID | 10961 |
|---|---|
| 著者 | Watanabe J, Ishihara K. |
| タイトル | Cell engineering biointerface focusing on cytocompatibility using phospholipid polymer with an isomeric oligo(lactic acid) segment. |
| ジャーナル | Biomacromolecules |
| Abstract |
Initial contact between a biological environment and a biomaterial ultimately decides the in vivo performance. Therefore, the fabrication of a delicate biointerface is important because it can be utilized as a platform for novel biomaterials. For the preparation of advanced biomedical devices such as biochips, nanoparticles, and cell engineering devices, the surface properties may be modified by the design of polymeric biomaterials. Anomalous phospholipid polymers with an isomeric oligo(lactic acid) segment were designed and evaluated as a biointerface. The phospholipid polymer containing 2-methacryloyloxyethyl phosphorylcholine was easily copolymerized with isomeric oligo(lactic acid) macromonomers, and the obtained polymer could easily form thin coating membranes as biointerfaces. The oligo(lactic acid) involves three kinds of isomers: dl-, d-, and l-forms. The favorable characteristic on the surface provides regulation of cell-material interactions on the biointerface. The oligo(lactic acid) segment could form hydrophobic domains, which were considered to be located on the interface, to enhance protein adsorption and cell adhesion. The most favorable characteristics on the biointerface were dual functions of cytocompatibility by the phospholipid polymer and cell adhesion property by the oligo(lactic acid) segment. In this study, we focused on the biological responses such as protein adsorption and cell adhesion by change in the oligo(lactic acid) component. The cell viability on the confluent stage was evaluated in terms of metabolic activity. |
| 巻・号 | 6(3) |
| ページ | 1797-802 |
| 公開日 | 2005-1-1 |
| DOI | 10.1021/bm050138f |
| PMID | 15877407 |
| MeSH | Animals Biomedical Engineering / methods* Cattle Cell Line Cell Survival / drug effects Fibroblasts / drug effects Lactic Acid / chemical synthesis* Lactic Acid / pharmacology Mice Phospholipids / chemical synthesis* Phospholipids / pharmacology Polymers / chemical synthesis* Polymers / pharmacology Surface Properties / drug effects |
| IF | 6.092 |
| 引用数 | 21 |
| WOS 分野 | POLYMER SCIENCE CHEMISTRY, ORGANIC BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | L929(RCB1451) |