RRC ID 11005
Author Okano T, Nakagawa T, Endo T, Kim TS, Kita T, Tamura T, Matsumoto M, Ohno T, Sakamoto T, Iguchi F, Ito J.
Title Engraftment of embryonic stem cell-derived neurons into the cochlear modiolus.
Journal Neuroreport
Abstract This study aimed to evaluate the potential of embryonic stem cell-derived neural progenitors for use as transplants for the replacement of the auditory primary neurons, spiral ganglion neurons. Mouse embryonic stem cell-derived neural progenitors were implanted into the base of the cochlear modiolus of normal or deafened guinea pigs, which contains spiral ganglion neurons and cochlear nerve fibers. Histological analysis demonstrated the survival and neural differentiation of transplants in the cochlear modiolus and active neurite outgrowth of transplants toward host peripheral or central auditory systems. Functional assessments indicated the potential of transplanted embryonic stem cell-derived neural progenitors to elicit the functional recovery of damaged cochleae. These findings support the hypothesis that transplantation of embryonic stem cell-derived neural progenitors can contribute to the functional restoration of spiral ganglion neurons.
Volume 16(17)
Pages 1919-22
Published 2005-11-28
DOI 10.1097/01.wnr.0000187628.38010.5b
PII 00001756-200511280-00010
PMID 16272879
MeSH Animals Auditory Pathways / cytology Auditory Pathways / surgery* Auditory Threshold Cochlear Nucleus / cytology Cochlear Nucleus / surgery* Deafness / surgery Guinea Pigs Mice Neurons / cytology Neurons / transplantation* Spiral Ganglion / cytology Spiral Ganglion / surgery* Stem Cell Transplantation* Transplantation, Heterologous
IF 1.266
Times Cited 39
Human and Animal Cells MC3T3-G2/PA6 (RCB1127)