| RRC ID |
1100
|
| Author |
Huaman MC, Yoshinaga K, Suryanatha A, Suarsana N, Kanbara H.
|
| Title |
Short report: polymorphisms in the chloroquine resistance transporter gene in Plasmodium falciparum isolates from Lombok, Indonesia.
|
| Journal |
Am J Trop Med Hyg
|
| Abstract |
The polymorphisms in the Plasmodium falciparum multidrug resistance 1 (pfmdr1) and P. falciparum chloroquine resistance transporter (pfcrt) genes, which are associated with chloroquine resistance, were examined in 48 P. falciparum isolates from uncomplicated malaria patients from the West Lombok District in Indonesia. The point mutation N86Y in pfmdr1 was present in 35.4% of the isolates and mutation K76T in pfcrt was found in all but one of the samples studied. Identified pfcrt haplotypes were mainly identical to the Papua New Guinea type S(agt)VMNT (42 of 48, 87.5%), and a few isolates had the Southeast Asia type CVIET (5 of 48, 10.4%). Moreover, one P. falciparum isolate harbored the K76N mutation, giving rise to the haplotype CVMNN, which was not previously reported in field isolates. Our findings suggest that chloroquine resistance in this area might have the same origin as in Papua New Guinea.
|
| Volume |
71(1)
|
| Pages |
40-2
|
| Published |
2004-7-1
|
| PII |
71/1/40
|
| PMID |
15238686
|
| MeSH |
Animals
Chloroquine / pharmacology*
DNA, Protozoan / chemistry
Drug Resistance / genetics*
Haplotypes
Humans
Indonesia
Membrane Proteins / genetics*
Membrane Transport Proteins
Plasmodium falciparum / drug effects
Plasmodium falciparum / genetics*
Polymorphism, Genetic
Protozoan Proteins
|
| IF |
2.126
|
| Times Cited |
22
|
|
WOS Category
|
TROPICAL MEDICINE
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
|
| Resource |
| Pathogenic microorganisms |
FCR3
K1
Pf005(3D7 clone)?
Pf089(3D7)? |
