論文 - 詳細
| RRC ID | 11055 |
|---|---|
| 著者 | Rodriguez I. |
| タイトル | Drosophila TIEG is a modulator of different signalling pathways involved in wing patterning and cell proliferation. |
| ジャーナル | PLoS One |
| Abstract |
Acquisition of a final shape and size during organ development requires a regulated program of growth and patterning controlled by a complex genetic network of signalling molecules that must be coordinated to provide positional information to each cell within the corresponding organ or tissue. The mechanism by which all these signals are coordinated to yield a final response is not well understood. Here, I have characterized the Drosophila ortholog of the human TGF-β Inducible Early Gene 1 (dTIEG). TIEG are zinc-finger proteins that belong to the Krüppel-like factor (KLF) family and were initially identified in human osteoblasts and pancreatic tumor cells for the ability to enhance TGF-β response. Using the developing wing of Drosophila as "in vivo" model, the dTIEG function has been studied in the control of cell proliferation and patterning. These results show that dTIEG can modulate Dpp signalling. Furthermore, dTIEG also regulates the activity of JAK/STAT pathway suggesting a conserved role of TIEG proteins as positive regulators of TGF-β signalling and as mediators of the crosstalk between signalling pathways acting in a same cellular context. |
| 巻・号 | 6(4) |
| ページ | e18418 |
| 公開日 | 2011-4-8 |
| DOI | 10.1371/journal.pone.0018418 |
| PMID | 21494610 |
| PMC | PMC3072976 |
| MeSH | Aging Alleles Amino Acid Sequence Animals Body Patterning* / genetics Cell Proliferation Drosophila Proteins / chemistry Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / chemistry* Drosophila melanogaster / embryology* Drosophila melanogaster / genetics Drosophila melanogaster / metabolism Gene Expression Regulation, Developmental Genes, Insect / genetics Genetic Complementation Test Humans Janus Kinases / metabolism Molecular Sequence Data Phenotype Repressor Proteins / metabolism STAT Transcription Factors / metabolism Sequence Homology, Amino Acid Signal Transduction* Transcription Factors / chemistry Transcription Factors / genetics Transcription Factors / metabolism* Up-Regulation / genetics Wings, Animal / cytology* Wings, Animal / embryology* Wings, Animal / metabolism |
| IF | 2.74 |
| 引用数 | 8 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | 4184R-4 4427R-1 |