RRC ID 11059
著者 Suissa Y, Ziv O, Dinur T, Arama E, Gerlitz O.
タイトル The NAB-Brk signal bifurcates at JNK to independently induce apoptosis and compensatory proliferation.
ジャーナル J Biol Chem
Abstract Apoptosis operates to eliminate damaged or potentially dangerous cells. This loss is often compensated by extra proliferation of neighboring cells. Studies in Drosophila imaginal discs suggest that the signal for the additional growth emanates from the dying cells. In particular, it was suggested that the initiator caspase Dronc mediates compensatory proliferation (CP) through Dp53 in wing discs. However, the exact mechanism that governs this CP remained poorly understood. We have previously shown that elimination of misspecified cells due to reduced Dpp signaling is achieved by the interaction of the co-repressor NAB with the transcriptional repressor Brk, which in turn induces Jun N-terminal kinase-dependent apoptosis. Here, we performed a systematic in vivo loss- and gain-of-function analysis to study NAB-induced death and CP. Our findings indicate that the NAB primary signal activates JNK, which in turn transmits two independent signals. One triggers apoptosis through the pro-apoptotic proteins Reaper and Hid, which in turn promote activation of caspases by the apoptosome components Ark and Dronc. The other signal induces CP in a manner that is independent of the death signal, Dronc, or Dp53. Once induced, the apoptotic pathway further activates a CP response. Our data suggest that JNK is the candidate factor that differentiates between apoptosis that involves CP and apoptosis that does not.
巻・号 286(17)
ページ 15556-64
公開日 2011-4-29
DOI 10.1074/jbc.M110.193235
PII S0021-9258(20)85839-6
PMID 21385866
PMC PMC3083146
MeSH Animals Apoptosis* Apoptosomes / metabolism Cell Proliferation* Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism* JNK Mitogen-Activated Protein Kinases / metabolism* Neuropeptides / metabolism Repressor Proteins / metabolism* Signal Transduction*
IF 4.238
引用数 15
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ショウジョウバエ 8091R-1