RRC ID 11078
著者 Rallis A, Moore C, Ng J.
タイトル Signal strength and signal duration define two distinct aspects of JNK-regulated axon stability.
ジャーナル Dev Biol
Abstract Signaling proteins often control multiple aspects of cell morphogenesis. Yet the mechanisms that govern their pleiotropic behavior are often unclear. Here we show activity levels and timing mechanisms determine distinct aspects of Jun N-terminal kinase (JNK) pathway dependent axonal morphogenesis in Drosophila mushroom body (MB) neurons. In the complete absence of Drosophila JNK (Basket), MB axons fail to stabilize, leading to their subsequent degeneration. However, with a partial loss of Basket (Bsk), or of one of the upstream JNK kinases, Hemipterous or Mkk4, these axons overextend. This suggests that Bsk activity prevents axons from destabilizing, resulting in degeneration and overextension beyond their terminal targets. These distinct phenotypes require different threshold activities involving the convergent action of two distinct JNK kinases. We show that sustained Bsk signals are essential throughout development and act additively but are dispensable at adulthood. We also suggest that graded Bsk inputs are translated into AP-1 transcriptional outputs consisting of Fos and Jun proteins.
巻・号 339(1)
ページ 65-77
公開日 2010-3-1
DOI 10.1016/j.ydbio.2009.12.016
PII S0012-1606(09)01421-3
PMID 20035736
PMC PMC2845820
MeSH Animals Axons* Drosophila MAP Kinase Kinase 4 / metabolism* Morphogenesis Phosphorylation
IF 2.896
引用数 20
WOS 分野 DEVELOPMENTAL BIOLOGY
リソース情報
ショウジョウバエ 15507R-4 2190R-1