RRC ID 11082
著者 Gubb D, Sanz-Parra A, Barcena L, Troxler L, Fullaondo A.
タイトル Protease inhibitors and proteolytic signalling cascades in insects.
ジャーナル Biochimie
Abstract Proteolytic signalling cascades control a wide range of physiological responses. In order to respond rapidly, protease activity must be maintained at a basal level: the component zymogens must be sequentially activated and actively degraded. At the same time, signalling cascades must respond precisely: high target specificity is required. The insects have a wide range of trapping- and tight-binding protease inhibitors, which can regulate the activity of individual proteases. In addition, the interactions between component proteases of a signalling cascade can be modified by serine protease homologues. The suicide-inhibition mechanism of serpin family inhibitors gives rapid turnover of both protease and inhibitor, but target specificity is inherently broad. Similarly, the TEP/macroglobulins have extremely broad target specificity, which suits them for roles as hormone transport proteins and sensors of pathogenic virulence factors. The tight-binding inhibitors, on the other hand, have a lock-and-key mechanism capable of high target specificity. In addition, proteins containing multiple tight-binding inhibitory domains may act as scaffolds for the assembly of signalling complexes. Proteolytic cascades regulated by combinations of different types of inhibitor could combine the rapidity of suicide-inhibitors with the specificity lock-and-key inhibitors. This would allow precise control of physiological responses and may turn out to be a general rule.
巻・号 92(12)
ページ 1749-59
公開日 2010-12-1
DOI 10.1016/j.biochi.2010.09.004
PII S0300-9084(10)00320-2
PMID 20850496
MeSH Animals Insect Proteins / metabolism* Insecta / metabolism* Macroglobulins / metabolism Peptide Hydrolases / metabolism* Protease Inhibitors / classification Protease Inhibitors / metabolism* Serpins / metabolism Signal Transduction*
IF 3.413
引用数 48
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ショウジョウバエ 4804R-1 8137R-3 4804R-1 9334R-3 9460R-3 127172R-1 10913R-1 12807R-1 6687R-1 1342R-1