論文 - 詳細
| RRC ID | 11094 |
|---|---|
| 著者 | Suissa Y, Kalifa Y, Dinur T, Graham P, Deshpande G, Schedl P, Gerlitz O. |
| タイトル | Hrp48 attenuates Sxl expression to allow for proper notch expression and signaling in wing development. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Different signaling pathways are deployed in specific developmental contexts to generate sexually dimorphic traits. Recently, Sex-lethal (Sxl), the female determinant in Drosophila melanogaster, was shown to down-regulate Notch (N) signaling to accomplish sex-specific patterning. Paradoxically, however, both Sxl and N are ubiquitously expressed in all of the female cells. This raises a key question as to how, during monomorphic female development, N signaling escapes the negative impact of Sxl. Here, we uncover a regulatory loop involving Hrp48, an abundant Drosophila hnRNP, Sxl and N. Phenotypic consequences of the partial loss of hrp48 resemble that of N but are more pronounced in females than in males. Likewise, N levels are drastically diminished only in females. Interestingly, monomorphic female tissues including wing, eye and antennal discs display considerable increase in Sxl amounts. Finally, female-specific attenuation of N signaling is rescued upon simultaneous removal of Sxl. Thus, our data demonstrate that in monomorphic contexts, Hrp48 functions as a moderator of Sxl expression to achieve adequate levels of N receptor production and signaling. We propose that it is critical to modulate the activities of the master determinant underling sexual dimorphism, to ensure that it does not function inappropriately in monomorphic tissues and disrupt their development. |
| 巻・号 | 107(15) |
| ページ | 6930-5 |
| 公開日 | 2010-4-13 |
| DOI | 10.1073/pnas.0910570107 |
| PII | 0910570107 |
| PMID | 20351283 |
| PMC | PMC2872424 |
| MeSH | Alleles Animals Crosses, Genetic Drosophila Proteins / metabolism* Drosophila Proteins / physiology* Drosophila melanogaster / metabolism* Female Gene Expression Regulation, Developmental* Heterogeneous-Nuclear Ribonucleoproteins / metabolism Heterogeneous-Nuclear Ribonucleoproteins / physiology* Male Mitosis Models, Biological RNA-Binding Proteins / metabolism* Receptors, Notch / metabolism* Sex Factors Signal Transduction Wings, Animal / embryology |
| IF | 9.412 |
| 引用数 | 15 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 10377R-1 18350R-3 |