Reference - Detail
| RRC ID | 11108 |
|---|---|
| Author | Jiang H, Edgar BA. |
| Title | EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. |
| Journal | Development |
| Abstract |
In holometabolous insects, the adult appendages and internal organs form anew from larval progenitor cells during metamorphosis. As described here, the adult Drosophila midgut, including intestinal stem cells (ISCs), develops from adult midgut progenitor cells (AMPs) that proliferate during larval development in two phases. Dividing AMPs first disperse, but later proliferate within distinct islands, forming large cell clusters that eventually fuse during metamorphosis to make the adult midgut epithelium. We find that signaling through the EGFR/RAS/MAPK pathway is necessary and limiting for AMP proliferation. Midgut visceral muscle produces a weak EGFR ligand, Vein, which is required for early AMP proliferation. Two stronger EGFR ligands, Spitz and Keren, are expressed by the AMPs themselves and provide an additional, autocrine mitogenic stimulus to the AMPs during late larval stages. |
| Volume | 136(3) |
| Pages | 483-93 |
| Published | 2009-2-1 |
| DOI | 10.1242/dev.026955 |
| PII | 136/3/483 |
| PMID | 19141677 |
| PMC | PMC2687592 |
| MeSH | Adult Stem Cells / cytology Adult Stem Cells / physiology Animals Cell Lineage / physiology Cell Proliferation* Drosophila / physiology* Drosophila Proteins / metabolism Drosophila Proteins / physiology* Epidermal Growth Factor / metabolism ErbB Receptors / physiology* Intestinal Mucosa / cytology* Intestinal Mucosa / growth & development Intestines / cytology* Intestines / growth & development Larva / growth & development Larva / physiology MAP Kinase Signaling System / physiology Membrane Proteins / metabolism Metamorphosis, Biological Neuregulins / metabolism Protein Binding Receptors, Invertebrate Peptide / physiology* Signal Transduction / physiology ras Proteins / physiology |
| IF | 5.611 |
| Times Cited | 162 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Resource | |
| Drosophila | |