論文 - 詳細
| RRC ID | 11136 |
|---|---|
| 著者 | Ninov N, Chiarelli DA, Martín-Blanco E. |
| タイトル | Extrinsic and intrinsic mechanisms directing epithelial cell sheet replacement during Drosophila metamorphosis. |
| ジャーナル | Development |
| Abstract |
The fusion of epithelial sheets is an essential morphogenetic event. Here, we study the development of the abdomen of Drosophila as a model of bounded epithelia expansion and uncover a complex multistep process for the generation of the adult epidermis from histoblasts, founder cells that replace the larval cells during metamorphosis. We find that histoblasts experience a biphasic cell cycle and emit apical projections that direct their invasive planar intercalation in between larval cells. Coordinately, the larval cells extrude from the epithelia by apical constriction of an actomyosin ring and as a consequence die by apoptosis and are removed by circulating haemocytes. We demonstrate that the proliferation of histoblasts and the death of larval cells are triggered by two independent extrinsic Ecdysone hormonal pulses. Finally, we show that histoblast spreading and the death of larval cells depend on a mutual exchange of signals and are non-autonomous processes. |
| 巻・号 | 134(2) |
| ページ | 367-79 |
| 公開日 | 2007-1-1 |
| DOI | 10.1242/dev.02728 |
| PII | dev.02728 |
| PMID | 17166923 |
| MeSH | Actins / metabolism Animals Animals, Genetically Modified Cell Communication Cell Cycle Cell Death Cell Proliferation Drosophila / cytology Drosophila / genetics Drosophila / growth & development* Drosophila / metabolism Drosophila Proteins / metabolism Ecdysone / metabolism Epithelial Cells / cytology Epithelial Cells / metabolism Genes, Insect Genotype Larva / cytology Larva / growth & development Metamorphosis, Biological Myosins / metabolism Signal Transduction |
| IF | 5.611 |
| 引用数 | 77 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ショウジョウバエ | NP line |