RRC ID |
11202
|
著者 |
Asaduzzaman SM, Nagao J, Iida H, Zendo T, Nakayama J, Sonomoto K.
|
タイトル |
Nukacin ISK-1, a bacteriostatic lantibiotic.
|
ジャーナル |
Antimicrob Agents Chemother
|
Abstract |
We determined the mode of action of nukacin ISK-1. It did not cause membrane potential dissipation or the efflux of ATP or K(+) ions from the cells of a sensitive bacterial strain; however, it blocked the membrane depolarization activity of nisin. Nukacin ISK-1-treated cells had single arrangements of cells without the formation of a complete septum. A remarkable reduction in cell wall width was also observed, but cytoplasmic content was unaffected. We concluded that nukacin ISK-1 is bacteriostatic.
|
巻・号 |
53(8)
|
ページ |
3595-8
|
公開日 |
2009-8-1
|
DOI |
10.1128/AAC.01623-08
|
PII |
AAC.01623-08
|
PMID |
19506061
|
PMC |
PMC2715603
|
MeSH |
Anti-Bacterial Agents / pharmacology
Bacillus subtilis / drug effects
Bacillus subtilis / metabolism
Bacillus subtilis / ultrastructure
Bacteriocins / chemistry
Bacteriocins / pharmacology*
Membrane Potentials / drug effects
Microscopy, Electron, Transmission
Models, Biological
Nisin / chemistry
Nisin / pharmacology
|
IF |
4.904
|
引用数 |
28
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
MICROBIOLOGY
|
リソース情報 |
一般微生物 |
JCM 1465
JCM 1157 |