| RRC ID |
11240
|
| Author |
Kômoto N, Quan GX, Sezutsu H, Tamura T.
|
| Title |
A single-base deletion in an ABC transporter gene causes white eyes, white eggs, and translucent larval skin in the silkworm w-3(oe) mutant.
|
| Journal |
Insect Biochem Mol Biol
|
| Abstract |
The w-3(oe) silkworm mutant has white eyes and eggs due to the absence of ommochrome pigments in the eye pigment cells and serosa cells. The mutant is also characterized by translucent larval skin resulting from a deficiency in the transportation of uric acid, which acts as a white pigment in larval epidermal cells. A silkworm homolog of the fruitfly white gene, Bmwh3, a member of ATP-binding cassette transporter superfamily, was mapped on the w-3 locus. The w-3(oe) mutant has a single-base deletion in exon 2 and a premature stop codon at the 5' end of exon 3. These results show that w-3 is equivalent to Bmwh3 and is responsible for the transportation of ommochrome precursors and uric acid into pigment granules and urate granules, respectively.
|
| Volume |
39(2)
|
| Pages |
152-6
|
| Published |
2009-2-1
|
| DOI |
10.1016/j.ibmb.2008.10.003
|
| PII |
S0965-1748(08)00184-7
|
| Description |
w-3(第３白卵）の原因遺伝子はABCトランスポーターfamilyに属するタンパク質をコードするBmwh3である。e03系統 (w-3oe/w-3oe)では、Bmwh3のエクソン2に 1bpの欠失がある。
|
| PMID |
18996197
|
| MeSH |
ATP-Binding Cassette Transporters / chemistry
ATP-Binding Cassette Transporters / genetics*
ATP-Binding Cassette Transporters / metabolism
Amino Acid Sequence
Animals
Base Sequence
Bombyx / chemistry
Bombyx / genetics*
Bombyx / metabolism
Eye / chemistry
Eye / metabolism
Eye Proteins / chemistry
Eye Proteins / genetics*
Eye Proteins / metabolism
Insect Proteins / chemistry
Insect Proteins / genetics*
Insect Proteins / metabolism
Molecular Sequence Data
Ovum / chemistry
Ovum / metabolism
Phenotype
Pigmentation
Point Mutation*
Sequence Alignment
Sequence Deletion
Skin / chemistry
Skin / metabolism
Uric Acid / metabolism
|
| IF |
3.827
|
| Times Cited |
58
|
|
WOS Category
|
ENTOMOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Silkworms |
e02
e03 |
