論文 - 詳細
| RRC ID | 11257 |
|---|---|
| 著者 | Orihara Y, Hamamoto H, Kasuga H, Shimada T, Kawaguchi Y, Sekimizu K. |
| タイトル | A silkworm baculovirus model for assessing the therapeutic effects of antiviral compounds: characterization and application to the isolation of antivirals from traditional medicines. |
| ジャーナル | J Gen Virol |
| Abstract |
Ganciclovir, foscarnet, vidarabine and ribavirin, which are used to treat viral infections in humans, inhibited the proliferation of a baculovirus (Bombyx mori nucleopolyhedrovirus) in BmN4 cells, a cultured silkworm cell line. These antiviral agents inhibited the proliferation of baculovirus in silkworm body fluid and had therapeutic effects. Using the silkworm infection model, the antiviral activity of Kampo medicines was screened and it was found that cinnamon bark, a component of the traditional Japanese medicine Mao-to, had a therapeutic effect. Based on the therapeutic activity, the antiviral substance was purified. Nuclear magnetic resonance analysis of the purified fraction revealed that the antiviral activity was due to cinnzeylanine, which has previously been isolated from Cinnamomum zeylanicum. Cinnzeylanine inhibits the proliferation of herpes simplex virus type 1 in Vero cells. These results suggest that the silkworm-baculovirus infection model is useful for screening antiviral agents that are effective for treating humans infected with DNA viruses. |
| 巻・号 | 89(Pt 1) |
| ページ | 188-194 |
| 公開日 | 2008-1-1 |
| DOI | 10.1099/vir.0.83208-0 |
| PMID | 18089742 |
| MeSH | Animals Antiviral Agents / therapeutic use* Baculoviridae / drug effects* Baculoviridae / growth & development* Baculoviridae / isolation & purification Bombyx / virology* Cinnamomum zeylanicum Female Humans Japan Ovum / virology Plant Extracts / therapeutic use* Viral Plaque Assay |
| IF | 3.376 |
| 引用数 | 35 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY VIROLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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