RRC ID 11268
著者 Kidokoro K, Ito K, Ogoyi DO, Abe H, Mita K, Kadono-Okuda K.
タイトル Non-susceptibility genes to Bombyx densovirus type 1, Nid-1 and nsd-1, affect distinct steps of the viral infection pathway.
ジャーナル J Invertebr Pathol
Abstract In the silkworm Bombyx mori, densovirus type 1 (BmDNV-1) replicates only in the midgut and causes fatal disease. Resistance to BmDNV-1 is determined by two genes, nsd-1 and Nid-1, respectively. Neither of them has been identified yet. We investigated the viral transcript by RT-PCR in inoculated silkworms carrying different sets of nsd-1 and Nid-1 genotype. BmDNV-1 transcript was not detected in nsd-1-carrying strains irrespective of existence of Nid-1 but clearly detected in strains carrying Nid-1 without nsd-1. The result suggests that nsd-1 blocks early step of infection. On the other hand, Nid-1 does not block cell and nucleus entry and viral transcription in nuclei but blocks later step in the viral infection cycle.
巻・号 103(1)
ページ 79-81
公開日 2010-1-1
DOI 10.1016/j.jip.2009.10.006
PII S0022-2011(09)00217-1
PMID 19836396
MeSH Animals Bombyx / genetics* Bombyx / virology* Densovirus / pathogenicity* Digestive System / virology Genes, Insect* Genetic Predisposition to Disease / genetics* Genotype Insect Viruses / pathogenicity
IF 2.074
引用数 9
WOS 分野 ZOOLOGY
リソース情報
カイコ n30