RRC ID 1127
Author Tsuda M, Sasaki M, Mugishima T, Komatsu K, Sone T, Tanaka M, Mikami Y, Kobayashi J.
Title Scalusamides A-C, new pyrrolidine alkaloids from the marine-derived fungus Penicillium citrinum.
Journal J. Nat. Prod.
Abstract Three new pyrrolidine alkaloids, scalusamides A-C (1-3), were isolated from the cultured broth of the fungus Penicillium citrinum, which was separated from the gastrointestine of a marine fish, and the structures were elucidated by spectroscopic data. The absolute stereochemistry of C-2 in the pyrrolidine unit was determined by HPLC analysis of a Marfey's derivative of the hydrolysate of 1, while that of 2 and 3 was assigned by comparison of spectroscopic data of 3 and reductive products of 1 and 2. On the other hand, each of 1-3 was found to be a mixture of epimers at C-7. Scalusamide A (1) exhibited antifungal and antibacterial activities.
Volume 68(2)
Pages 273-6
Published 2005-2
DOI 10.1021/np049661q
PMID 15730261
MeSH Alkaloids / chemistry Alkaloids / isolation & purification* Alkaloids / pharmacology Animals Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / isolation & purification* Anti-Bacterial Agents / pharmacology Antifungal Agents / chemistry Antifungal Agents / isolation & purification* Antifungal Agents / pharmacology Chromatography, High Pressure Liquid Fishes Japan Molecular Structure Nuclear Magnetic Resonance, Biomolecular Penicillium / chemistry* Pyrrolidines / chemistry Pyrrolidines / isolation & purification* Pyrrolidines / pharmacology
IF 4.257
Times Cited 23
Pathogenic microorganisms P. citrinum?