RRC ID |
1127
|
Author |
Tsuda M, Sasaki M, Mugishima T, Komatsu K, Sone T, Tanaka M, Mikami Y, Kobayashi J.
|
Title |
Scalusamides A-C, new pyrrolidine alkaloids from the marine-derived fungus Penicillium citrinum.
|
Journal |
J Nat Prod
|
Abstract |
Three new pyrrolidine alkaloids, scalusamides A-C (1-3), were isolated from the cultured broth of the fungus Penicillium citrinum, which was separated from the gastrointestine of a marine fish, and the structures were elucidated by spectroscopic data. The absolute stereochemistry of C-2 in the pyrrolidine unit was determined by HPLC analysis of a Marfey's derivative of the hydrolysate of 1, while that of 2 and 3 was assigned by comparison of spectroscopic data of 3 and reductive products of 1 and 2. On the other hand, each of 1-3 was found to be a mixture of epimers at C-7. Scalusamide A (1) exhibited antifungal and antibacterial activities.
|
Volume |
68(2)
|
Pages |
273-6
|
Published |
2005-2-1
|
DOI |
10.1021/np049661q
|
PMID |
15730261
|
MeSH |
Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology
Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Antifungal Agents / chemistry
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Chromatography, High Pressure Liquid
Fishes
Japan
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Penicillium / chemistry*
Pyrrolidines / chemistry
Pyrrolidines / isolation & purification*
Pyrrolidines / pharmacology
|
IF |
3.782
|
Times Cited |
31
|
WOS Category
|
PHARMACOLOGY & PHARMACY
PLANT SCIENCES
CHEMISTRY, MEDICINAL
|
Resource |
Pathogenic microorganisms |
P. citrinum? |