論文 - 詳細
RRC ID | 1127 |
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著者 | Tsuda M, Sasaki M, Mugishima T, Komatsu K, Sone T, Tanaka M, Mikami Y, Kobayashi J. |
タイトル | Scalusamides A-C, new pyrrolidine alkaloids from the marine-derived fungus Penicillium citrinum. |
ジャーナル | J Nat Prod |
Abstract |
Three new pyrrolidine alkaloids, scalusamides A-C (1-3), were isolated from the cultured broth of the fungus Penicillium citrinum, which was separated from the gastrointestine of a marine fish, and the structures were elucidated by spectroscopic data. The absolute stereochemistry of C-2 in the pyrrolidine unit was determined by HPLC analysis of a Marfey's derivative of the hydrolysate of 1, while that of 2 and 3 was assigned by comparison of spectroscopic data of 3 and reductive products of 1 and 2. On the other hand, each of 1-3 was found to be a mixture of epimers at C-7. Scalusamide A (1) exhibited antifungal and antibacterial activities. |
巻・号 | 68(2) |
ページ | 273-6 |
公開日 | 2005-2-1 |
DOI | 10.1021/np049661q |
PMID | 15730261 |
MeSH | Alkaloids / chemistry Alkaloids / isolation & purification* Alkaloids / pharmacology Animals Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / isolation & purification* Anti-Bacterial Agents / pharmacology Antifungal Agents / chemistry Antifungal Agents / isolation & purification* Antifungal Agents / pharmacology Chromatography, High Pressure Liquid Fishes Japan Molecular Structure Nuclear Magnetic Resonance, Biomolecular Penicillium / chemistry* Pyrrolidines / chemistry Pyrrolidines / isolation & purification* Pyrrolidines / pharmacology |
IF | 3.782 |
引用数 | 31 |
WOS 分野 | PHARMACOLOGY & PHARMACY PLANT SCIENCES CHEMISTRY, MEDICINAL |
リソース情報 | |
病原微生物 | P. citrinum? |